Esta sección incluye una lista de los últimos artículos científicos del IPNA publicados en revistas incluidas en el Science Citation Index (SCI).

En DIGITAL.CSIC, repositorio institucional del CSIC, pueden encontrar el listado completo de artículos científicos desde 1962, así como otras colecciones de interés como congresos, tesis, libros, material divulgativo, etc. del centro. El objetivo de DIGITAL.CSIC es organizar, preservar y difundir en acceso abierto los resultados de nuestra investigación.

En el repositorio institucional del CSIC, pueden encontrar el listado completo de artículos científicos, así como otras colecciones de interés como congresos, tesis, libros, material divulgativo, etc.

Ir a Digital - CSIC


Análisis de la Producción Científica del IPNA 2014-2019: análisis bibliométrico realizado a partir de datos recogidos en Scopus y Web of Science.

Digital CSIC

Collective and harmonized high throughput barcoding of insular arthropod biodiversity: Toward a Genomic Observatories Network for islands

Current understanding of ecological and evolutionary processes underlying island biodiversity is heavily shaped by empirical data from plants and birds, although arthropods comprise the overwhelming majority of known animal species, and as such can provide key insights into processes governing biodiversity. Novel high throughput sequencing (HTS) approaches are now emerging as powerful tools to overcome limitations in the availability of arthropod biodiversity data, and hence provide insights into these processes. Here, we explored how these tools might be most effectively exploited for comprehensive and comparable inventory and monitoring of insular arthropod biodiversity. We first reviewed the strengths, limitations and potential synergies among existing approaches of high throughput barcode sequencing. We considered how this could be complemented with deep learning approaches applied to image analysis to study arthropod biodiversity. We then explored how these approaches could be implemented within the framework of an island Genomic Observatories Network (iGON) for the advancement of fundamental and applied understanding of island biodiversity. To this end, we identified seven island biology themes at the interface of ecology, evolution and conservation biology, within which collective and harmonized efforts in HTS arthropod inventory could yield significant advances in island biodiversity research.

Emerson, Brent C.; Borges, Paulo A. V.; Cardoso, Pedro; Convey, Peter; deWaard, Jeremy R.; Economo, Evan P.; Gillespie, Rosemary G.; Kennedy, Susan; Krehenwinkel, Henrik; Meier, Rudolf; Roderick, George K.; Strasberg, Dominique; Thébaud, Christophe; Traveset, Anna; Creedy, Thomas J.; Meramveliotakis, Emmanouil; Noguerales, Víctor; Overcast, Isaac; Morlon, Hélène; Papadopoulou, Anna; Vogler, Alfried P.; Arribas, Paula; Andújar, Carmelo.

Molecular Ecology : 1-16 (2022)

Iron(III)-Catalyzed Synthesis of 2‑Alkyl Homoallyl Sulfonyl Amides: Antiproliferative Study and Reactivity Scope of Aza-Prins Cyclization

A direct, catalytic, and complementary method to obtain 2-substituted homoallyl sulfonyl amides is described, starting from sulfonyl amides, aldehydes, and allyltrimethylsilane using iron(III) chloride as a sustainable catalyst. The scope of the process and the reactivity in aza-Prins cyclization is evaluated and supported by density functional theory (DFT) studies. Finally, an evaluation of the antiproliferative activity for this family of sulfonyl amides is also included.

Carballo, Rubén M.; Padrón, José M.; Fernández, Israel; Cruz, Daniel A.; Grmusa, Luana; Martín, Víctor S.; Padrón, Juan I.

Journal of Organic Chemistry

Synthesis of Tetrahydroazepines through Silyl Aza-Prins Cyclization Mediated by Iron(III) Salts

A new methodology for the synthesis of sevenmembered unsaturated azacycles (tetrahydroazepines) was developed. It is based on the powerful aza-Prins cyclization in combination with the Peterson-type elimination reaction. In a single reaction step, a C−N, C− C bond and an endocyclic double bond are formed. Under mild reaction conditions and using iron(III) salts as sustainable catalysts, tetrahydroazepines with different degrees of substitution are obtained directly and efficiently. DFT calculations supported the proposed mechanism.

Sinka, Victoria; Fernández, Israel; Padrón, Juan I.

Journal of Organic Chemistry

Synthesis of Oxazole–Tetrahydropyran Hybrids and Study on Their Antiproliferative Activity Against Human Tumour Cells

A series of triazole linked tetrahydropyran–oxazole hybrids was synthesized based on a previously reported lead compound with selective antiproliferative activity against human tumour cell lines. The series was prepared to evaluate the impact of LogP and different modifications in the activity, and the new compounds were assayed against A549, HBL-100, HeLa, SW1573, T-47D, and WiDr cell lines. Also, the potentiality to be P-gp substrate was tested. The compounds exhibited good antiproliferative results when compared with the standards cisplatin and 5-fluorouracil. In silico studies to evaluate pharmacokinetic properties using pkCSM software were also carried out.

Quintana, Vanesa; González-Bakker, Aday; Padrón, Juan I.; Martín, Víctor S.; Padrón, José M.; Davyt, Danilo; Valdomir, Guillermo.

European Journal of Organic Chemistry

Effects of Phytogenically Synthesized Bimetallic Ag/ZnO Nanomaterials and Nitrogen-Based Fertilizers on Biochemical and Yield Attributes of Two Wheat Varieties

Wheat is the most important staple food worldwide, but wheat cultivation faces challenges from high food demand. Fertilizers are already in use to cope with the demand; however, more unconventional techniques may be required to enhance the efficiency of wheat cultivation. Nanotechnology offers one potential technique for improving plant growth and production by providing stimulating agents to the crop. In this study, plant-derived Ag/ZnO nanomaterials were characterized using UV-Vis spectroscopy, SEM, EDX, FTIR, and XRD methods. Various concentrations of phytogenically synthesized Ag/ZnO nanomaterials (20, 40, 60, and 80 ppm) and nitrogen-based fertilizers (urea and ammonium sulphate 50 and 100 mg/L) were applied to wheat varieties (Galaxy-13 and Pak-13). The results obtained from this research showed that application of 60 ppm Ag/ZnO nanomaterials with nitrogenous fertilizers (50 and 100 mg/L) were more effective in improving biochemistry and increasing yield of wheat plants by reducing enzymatic and non-enzymatic antioxidants (proline content, soluble sugar content, malondialdehyde, total phenolic content, total flavonoid content, superoxide dismutase, peroxidase, and catalase); and significantly increasing the protein content, number of grains per pot, spike length, 100-grain weight, grain yield per pot, and harvest index of both wheat varieties, compared to untreated plants. These findings allow us to propose Ag/ZnO nanomaterial formulation as a promising growth- and productivity-improvement strategy for wheat cultivation.

Ehsan, Maria; Iqbal Raja, Naveed; Mashwani, Zia Ur Rehman; Zohra, Efat; Abasi, Fozia; Ikram, Muhammad; Mustafa, Nilofar; Hamid Wattoo, Feroza; Procków, Jarosław; Pérez de Lastra, José Manuel.

Nanomaterials, 12(17), 2894 : 1-23 (2022)

Efficient Oral Priming of Tenebrio molitor Larvae Using Heat-Inactivated Microorganisms

Microbial resistance is a global health problem that will increase over time. Advances in insect antimicrobial peptides (AMPs) offer a powerful new approach to combat antimicrobial resistance. Invertebrates represent a rich group of animals for the discovery of new antimicrobial agents due to their high diversity and the presence of adaptive immunity or “immune priming”. Here, we report a priming approach for Tenebrio molitor that simulates natural infection via the oral route. This oral administration has the advantage of minimizing the stress caused by conventional priming techniques and could be a viable method for mealworm immunity studies. When using inactivated microorganisms for oral priming, our results showed an increased survival of T. molitor larvae after exposure to various pathogens. This finding was consistent with the induction of antimicrobial activity in the hemolymph of primed larvae. Interestingly, the hemolymph of larvae orally primed with Escherichia coli showed constitutive activity against Staphylococcus aureus and heterologous activity for other Gram-negative bacteria, such as Salmonella enterica. The priming of T. molitor is generally performed via injection of the microorganism. To our knowledge, this is the first report describing the oral administration of heat-inactivated microorganisms for priming mealworms. This technique has the advantage of reducing the stress that occurs with the conventional methods for priming vertebrates.

González-Acosta, Sergio; Baca-González, Victoria; Asensio-Calavia, Patricia; Otazo-Pérez, Andrea; López, Manuel R.; Morales-delaNuez, Antonio; Pérez de Lastra, José Manuel.

Vaccines, 10(8), 1296 : 1-11 (2022)

Modulation of Popocatépetl’s activity by regional and worldwide earthquakes

Volcanoes switching from quiescence to eruption shortly after catastrophic earthquakes have raised interest for volcanic triggering and the influence of earthquakes on volcanic activity. Its influence on already active systems and especially at open-vent volcanoes is more difficult to apprehend. A number of recent observations suggest an influence of tectonic earthquakes on Popocatépetl’s activity, the importance of which remains unknown. To further investigate this, we introduce an index, based on the near-field concept, identifying the earthquakes with the highest potential to promote volcanic activity (hereafter termed “significant earthquakes”). The time series of significant earthquakes is compared with the intensity of the volcanic activity, as characterized by the number and energy of volcano-tectonic earthquakes, the number of dome extrusions, the intensity of thermal and degassing fluxes, and ash production. Three main periods with contrasting activity stand out showing that Popocatépetl presents intense activity when significant tectonic earthquakes are frequent. Enhanced extrusion apparently follows significant earthquakes quickly with pulses of dome extrusion that peak after 1.3 ± 0.3 years. Conversely, extrusive activity vanishes when significant seismicity disappears, as during the period 2003–2011, which coincides with a 12-year-long significant seismicity gap. Hence, we propose that the 1994–2022 open-vent activity at Popocatépetl is in part modulated by the repetitive occurrence of significant earthquakes that periodically promote volcanic activity.

Boulesteix, Thomas; Legrand, Denis;Taquet, Noémie; Coppola, Diego; Laiolo, Marco; Valade, Sébastien; Massimetti, Francesco; Caballero-Jiménez, Gema; Campion, Robin.

Bulletin of Volcanology, 84 (2022)

Solid-Supported Tetrahydropyran-Based Hybrid Dipeptide Catalysts for Michael Addition of Aldehydes to Nitrostyrenes

The heterogenization of homogeneous catalysts onto a solid support is a step towards a more sustainable chemistry. The recovery and reuse of catalysts is extremely important from a practical, economic and environmental point of view. In this regards, we report a series of polymer-supported tetrahydropyran-based hybrid dipeptides that serve as active catalysts for the enantioselective Michael addition of aldehydes to β-nitrostyrenes. These supported catalysts have been designed considering the optimal anchor position and orientation between the catalyst and the solid support. Additionally, the influence of the linker length on the catalytic efficiency was studied. The catalysts allowed the transformation of a variety of substrates in 76–98% yield and with 94–97% enantiomeric excess. Detailed deactivation studies have provided important information, which allows to increase the useful life of these immobilized catalysts.

García-Monzón, Irma; Borges-González, Jorge; Martín, Tomás

Advanced Synthesis & Catalysis 2022, 364

Shortest Enantioselective Total Syntheses of (+)-Isolaurepinnacin and (+)-Neoisoprelaurefucin

The shortest enantioselective total syntheses of (+)-isolaurepinnacin and (+)-neoisoprelaurefucin have been accomplished. These syntheses were based on a common parallel synthetic strategy using Prins–Peterson cyclization in their core construction. In only one step, a seven-membered ring oxacycle with the correct cis-stereochemistry ring closure and the Δ4 position of the endocyclic double bond in (+)-isolaurepinnacin was obtained. This unsaturation was also necessary to accede to the bromodioxabicycle on (+)-neoisoprelaurefucin.

Sinka, Victoria; Cruz, Daniel A.; Martín, Víctor S.; Padrón, Juan I.

Organic Letters 2022, 24, 29, 5271–5275

Chemistry of Hydrogen Peroxide Formation and Elimination in Mammalian Cells, and Its Role in Various Pathologies

Hydrogen peroxide (H2O2) is a compound involved in some mammalian reactions and processes. It modulates and signals the redox metabolism of cells by acting as a messenger together with hydrogen sulfide (H2S) and the nitric oxide radical (•NO), activating specific oxidations that determine the metabolic response. The reaction triggered determines cell survival or apoptosis, depending on which downstream metabolic pathways are activated. There are several ways to produce H2O2 in cells, and cellular systems tightly control its concentration. At the cellular level, the accumulation of hydrogen peroxide can trigger inflammation and even apoptosis, and when its concentration in the blood reaches toxic levels, it can lead to bioenergetic failure. This review summarizes existing research from a chemical perspective on the role of H2O2 in various enzymatic pathways and how this biochemistry leads to physiological or pathological responses.

Curieses Andrés, Celia María; Pérez de Lastra, José Manuel; Andrés Juan, Celia; Plou Gasca, Francisco José; Pérez-Lebeña, Eduardo.

Stresses, 2 (3) : 256-274 (2022)