Publications

This section includes a list of the latest IPNA scientific articles published in journals included in the Science Citation Index (SCI).

In DIGITAL.CSIC, institutional repository of the CSIC, you can find the complete list of scientific articles since 1962, as well as other collections of interest such as congresses, theses, books, informative material, etc. of the centre. The aim of DIGITAL.CSIC is to organize, preserve and disseminate in open access the results of our research.

In the institutional repository of the CSIC, you can find the complete list of scientific articles, as well as other collections of interest such as congresses, theses, books, informative material, etc.

Go to Digital - CSIC

 

Analysis of the IPNA 2014-2019 Scientific Production: bibliometric analysis from data collected in Scopus and Web of Science.

 

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Digital CSIC

Combating water stress in Macaronesia

Decreasing water resources is a pressing climate change issue, with crop productivity and food security highly dependent on irrigation. At IPNA-CSIC, Dr Andrés A Borges and his colleagues have launched AHIDAGRO, a project committed to achieving agricultural sustainability in Macaronesia. AHIDAGRO addresses challenges associated with water stress in plants by developing natural products and solutions that protect crops during water-deficit periods. To date, they have developed new methods for evaluating biostimulants and tested new biostimulants in field conditions. The findings offer a resource for communities struggling with water shortages worldwide.

Borges, Andrés A.

Research Features : 1-2 (2022)
DOIDigital.CSIC

Betelvine (Piper betle L.): A comprehensive insight into its ethnopharmacology, phytochemistry, and pharmacological, biomedical and therapeutic attributes

Piper betle L. (synonym: Piper betel Blanco), or betel vine, an economically and medicinally important cash crop, belongs to the family Piperaceae, often known as the green gold. The plant can be found all over the world and is cultivatedprimarily in South East Asian countries for its beautiful glossy heart-shaped leaves, which are chewed or consumed as betelquidand widely used in Chinese and Indian folk medicine, as carminative, stimulant,astringent, against parasitic worms, conjunctivitis, rheumatism, wound, etc., andis also used for religious purposes. Hydroxychavicol is the most important bioactive compound among the wide range of phytoconstituents found in essential oil and extracts. The pharmacological attributes of P. betle are antiproliferation, anticancer, neuropharmacological, analgesic, antioxidant, antiulcerogenic, hepatoprotective, antifertility, antibacterial, antifungal and many more. Immense attention has been paid to nanoformulations and their applications. The application of P. betle did not show cytotoxicity in preclinical experiments, suggesting that it could serve as a promising therapeutic candidate for different diseases. The present review comprehensively summarizes the botanical description, geographical distribution, economic value and cultivation, ethnobotanical uses, preclinical pharmacological properties with insights of toxicological, clinical efficacy, and safety of P. betle. The findings suggest that P. betle represents an orally active and safe natural agent that exhibits great therapeutic potential for managing various human medical conditions. However, further research is needed to elucidate its underlying molecular mechanisms of action, clinical aspects, structure–activity relationships, bioavailability and synergistic interactions with other drugs.

Biswas, Protha; Anand, Uttpal; Chatterjee, Suchismita (Saha); Kant, Nishi; Mishra, Tulika; Masih, Harison; Bar, Ananya; Kumar Pandey, Devendra; Kumar Jha, Niraj; Majumder, Madhumita; Das, Neela; Gadekar, Vijaykumar Shivaji; Shekhawat, Mahipal S.; Kumar, Manoj; Radha; Proćków, Jarosław; Pérez de la Lastra, José M.; Dey, Abhijit

Journal of Cellular and Molecular Medicine : 1-37 (2022)
DOIDigital.CSIC

DNA barcoding reveals new records of invasive terrestrial flatworms (Platyhelminthes, Tricladida, Geoplanidae) in the Macaronesian region

Oceanic islands harbour a limited richness of native land planarians, likely explained in large part by their inability to survive long periods of immersion in salt water (Winsor et al. 2004). Instead, most land planarians on islands are the result of introductions (e.g. Justine et al. 2018a; b; Lago-Barcia et al. 2020; Suárez et al. 2018; Winsor et al. 2004), likely due to the global trade of plants, as planarians can be inadvertently transported in the humid soil of pots (Álvarez-Presas et al. 2014; Winsor et al. 2004). Planarians are generalist predators (Sluys 1999) and a potential threat for native invertebrate fauna. Thus, the group has become of interest with regard to understanding the expansions of species distributions into non-native areas. We report here the presence of three invasive land planarian species within oceanic islands of the Macaronesian region: Obama nungara Carbayo, (Carbayo et al. 2016) (new for the Canary Islands), Caenoplana coerulea (Moseley 1877) (new for Madeira) and Endeavouria septemlineata (Hyman 1939) (new for the Canary Islands and Madeira).

Suárez, Daniel; Pedrianes, Juan Ramón; Andújar, Carmelo.

Zootaxa: 1-4 (2022)
DOIDigital.CSIC

Certification of Natural Wine: Policy Controversies and Future Prospects

Natural wine is made from grapes produced under organic or biodynamic management without using additives in the cellar. Natural wine represents a movement of winegrowers that see agriculture as an ethical act against wine industrialization and as a way to make food systems more sustainable. The movement has gained fast-growing global fame and connects rural producers with urban consumers. The recent French recognition of a natural wine certification has spurred discontent among other European countries and wine business associations. A debate about the policy implications of natural wine certification is necessary in order to shed light on the matter. This article calls for transparency in the labeling of wine ingredients, in line with recent consumer demands, which would make the creation of new certifications redundant.

Alonso-González, Pablo; Parga-Dans, Eva; Fuentes Fernández, Rosana.

Front. Sustain. Food Syst. 6 : 1-5 (2022)
DOIDigital.CSIC

Structural diversity using amino acid “Customizable Units”: conversion of hydroxyproline (Hyp) into nitrogen heterocycles

The ability of amino acid “customizable units” to generate structural diversity is illustrated by the conversion of 4-hydroxyproline (Hyp) units into a variety of nitrogen heterocycles. After a frst common step, where the unit underwent a one-pot decarboxylation–alkylation reaction to aford 2-alkylpyrrolidines with high stereoselectivity, a divergent step was carried out. Thus, the deprotected 4-hydroxy group was used either to initiate a radical scission that aforded aliphatic β-amino aldehydes, or to carry out an elimination reaction, to give 2-alkyl-2,5-dihydro-1H-pyrroles. In the frst case, the amines underwent a tandem reductive amination–cyclization to aford β-amino-δ-lactams, an efcient rigidifying unit in peptides. Diferent lactam N-substituents, such as alkylamines, peptides, and alkenyl chains suitable for olefn metathesis were introduced this way. In the second case, the pyrrole derivatives were efciently converted into alkaloid and iminosugar derivatives in good global yields and with excellent stereoselectivity.

Hernández, Dácil; Porras, Marina; Boto, Alicia.

Amino Acids: 1-12 (2022)
DOIDigital.CSIC

Subduction earthquakes controlled by incoming plate geometry: The 2020 M > 7.5 Shumagin, Alaska, earthquake doublet

In 2020, an earthquake doublet, a M7.8 on July 22nd and a M7.6 on October 19th, struck the Alaska-Aleutian subduction zone beneath the Shumagin Islands. This is the first documented earthquake doublet involving a megathrust event and a strike-slip event. The first event partially ruptured a seismic gap, which has not hosted large earthquakes since 1917, and the second event was unusual as it broke a trench-perpendicular fault within the incoming oceanic slab. We used an improved Bayesian geodetic inversion method to estimate the fault slip distributions of the major earthquakes using Interferometric Synthetic Aperture Radar (InSAR) wrapped phase and Global Navigation Satellite Systems (GNSS) offsets data. The geodetic inversions reveal that the Shumagin seismic gap is multi-segmented, and the M7.8 earthquake ruptured the eastern segment from 14 km down to 44 km depth. The coseismic slip occurred along a more steeply, 26◦ dipping segment, and was bounded up-dip by a bend of the megathrust interface to a shallower 8◦ dip angle connecting to the trench. The model for the M7.6 event tightly constrained the rupture depth extent to 19-39 km, within the depth range of the M7.8 coseismic rupture area. We find that the M7.6 event ruptured the incoming slab across its full seismogenic thickness, potentially reactivating subducted Kula-Resurrection seafloor-spreading ridge structures. Coulomb stress transfer models suggest that coseismic and/or postseismic slip of the M7.8 event could have triggered the M7.6 event. We conclude that the segmented megathrust structure and the location of intraslab fault structures limited the rupture dimensions of the M7.8 event and are responsible for the segmentation of the Shumagin seismic gap. Our study suggests that the western and shallower up-dip segments of the seismic gap did not fail and remain potential seismic and tsunami hazard sources. The unusual earthquake doublet provides a unique opportunity to improve our understanding of the role of the subducting lithosphere structure in the segmentation of subduction zones.

Yu, Jiang; González Méndez, Pablo José; Bürgmann, Roland.

Earth and Planetary Science Letters 584, 117447: 1-13 (2022)
DOIDigital.CSIC

Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics

Cancer is an abnormal state of cells where they undergo uncontrolled proliferation and produce aggressive malignancies that cause millions of deaths every year. With the new understanding of the molecular mechanism(s) of disease progression, our knowledge about the disease is snowballing, leading to the evolution of many new therapeutic regimes and their successive trials. In the past few decades, various combinations of therapies have been proposed and are presently employed in the treatment of diverse cancers. Targeted drug therapy, immunotherapy, and personalized medicines are now largely being employed, which were not common a few years back. The field of cancer discoveries and therapeutics are evolving fast as cancer type-specific biomarkers are progressively being identified and several types of cancers are nowadays undergoing systematic therapies, extending patients’ disease-free survival thereafter. Although growing evidence shows that a systematic and targeted approach could be the future of cancer medicine, chemotherapy remains a largely opted therapeutic option despite its known side effects on the patient’s physical and psychological health. Chemotherapeutic agents/pharmaceuticals served a great purpose over the past few decades and have remained the frontline choice for advanced-stage malignancies where surgery and/or radiation therapy cannot be prescribed due to specific reasons. The present report succinctly reviews the existing and contemporary advancements in chemotherapy and assesses the status of the enrolled drugs/pharmaceuticals; it also comprehensively discusses the emerging role of specific/targeted therapeutic strategies that are presently being employed to achieve better clinical success/survival rate in cancer patients.

Anand, Uttpal; Dey, Abhijit; Chandel, Arvind K. Singh; Sanyal, Rupa; Mishra, Amarnath; Pandey, Devendra Kumar; De Falco, Valentina; Upadhyay, Arun; Kandimalla, Ramesh; Chaudhary, Anupama; Dhanjal, Jaspreet Kaur; Dewanjee, Saikat; Vallamkondu, Jayalakshmi; Pérez De La Lastra, José M.

Genes & Diseases : 1-35 (2022)
DOIDigital.CSIC

New Biostimulants Screening Method for Crop Seedlings under Water Deficit Stress

Biostimulants can be used in many crops growing under water deficit conditions at the seedling stage. This study used tomato, Solanum lycopersicum L., seedlings growing in commercial 150-cell trays as an experimental setup to reproduce mild drought stress effects. The method showed significant reductions in seedling growth and RGR (25%) after a seven-day experiment. Gas exchange parameters (Pn, Gs and E) had significantly lower values (30–50%) than the control seedlings. Stress-related metabolite, ABA, exhibited a significant accumulation in the tomato seedlings (24 h), consistent with SINCED2 gene expression. Proline levels were twice as high in the water-deficit treated seedlings, remaining at this level until the end of the experiment. However, total carbohydrates were significantly lower in water-deficit treated seedlings. Qualitative and quantitative analysis suggested that using the variable ‘seedling biomass accumulation’ could simplify the methodology. Twelve different biostimulants were assayed, implementing this simplification, and all of them showed higher biomass accumulation in the treated seedlings than in the non-treated ones under water deficit. Among them, putrescine, spermine and spermidine were the most effective. The method is adjustable to different biostimulant volumes (1, 3 and 5 mL; 1 mM BABA), with no significant differences between the treatments.

Jiménez-Arias, David; Morales-Sierra, Sarai; Borges, Andrés A.; Herrera, Antonio J.; Luis, Juan C.

Agronomy 12(3), 728: 1-15 (2022)
DOIDigital.CSIC

A new cavernicolous assassin bug from the Canary Islands (Hemiptera: Reduviidae: Emesinae: Collartidini)

The Canary Archipelago is home to two species of obligately cavernicolous assassin bugs of the genus Collartida Villiers, 1949 (Hemiptera: Heteroptera: Reduviidae: Emesinae: Collartidini). These species are highly adapted for cave life, being blind and wingless. In the present study, we describe a new species of the genus, C. phantasma sp. nov. from the Federica mine in Gran Canaria. C. phantasma sp. nov. differs from the other two Collartida species found in the Canary Archipelago in that the male is fully winged, the female is wingless, and both sexes have well-developed eyes. We provide information regarding the new species’ habitat, its taxonomic affinities, and its ability to fly.

Davranoglou, Leonidas-Romanos; Baňař, Petr; Suárez, Daniel; Martín, Sonia; Naranjo, Manuel.

Zootaxa 5115(3): 342–360 (2022)
DOIDigital.CSIC

Mapping stressed wheat plants by soil aluminum efect using C‑band SAR images: implications for plant growth and grain quality

Under toxic aluminum (Al) levels in the soil, wheat (Triticum aestivum L.) sufers stress and plant growth is afected. A method for diagnosis of plants is proposed that includes the following as a strategy: to analyze total Al in the soil, employ satellite radar imagery and calculate a vegetation index. The objective of this research, conducted at the feld scale, was to explore how radar backscattering coefcients from a winter wheat canopy, combined with the normalized diference vegetation index (NDVI) and geographic information system (GIS) technology, can be used as a mapping tool for the variability of Al-stressed canopies. As a result, an analysis of covariance showed signifcant diferences, and the lowest plant height was obtained at a high level of soil Al, as well as the minimum grain weight and magnesium content. It was found that a simple model could be used to estimate plant height from the backscattering coefcient of vertical transmit-vertical receive polarization (σ°VV), with a strong correlation (r−0.84). In turn, a third-order polynomial regression model (R20.70) was proposed to estimate the NDVI from σ°VV. This model provided a good estimate of the NDVI at the stem elongation stage of growth (50 days after sowing). Detected NDVI patterns were associated with variation in canopy stress depending on polarimetric information, which, in turn, was related to soil Al levels. Thus, the maps derived from the model can monitor spatial variability, where NDVI values<0.68 indicate stressed areas. This study provides guidance for in-season stress spatial variability caused by Al.

Hernández, Mercedes; Borges, Andrés A.; Francisco‑Bethencourt, Desiderio.

Precision Agriculture 1-21 (2022)
DOIDigital.CSIC