Esta sección incluye una lista de los últimos artículos científicos del IPNA publicados en revistas incluidas en el Science Citation Index (SCI).

En DIGITAL.CSIC, repositorio institucional del CSIC, pueden encontrar el listado completo de artículos científicos desde 1962, así como otras colecciones de interés como congresos, tesis, libros, material divulgativo, etc. del centro. El objetivo de DIGITAL.CSIC es organizar, preservar y difundir en acceso abierto los resultados de nuestra investigación.

En el repositorio institucional del CSIC, pueden encontrar el listado completo de artículos científicos, así como otras colecciones de interés como congresos, tesis, libros, material divulgativo, etc.

Ir a Digital - CSIC


Análisis de la Producción Científica del IPNA 2014-2019: análisis bibliométrico realizado a partir de datos recogidos en Scopus y Web of Science.

Digital CSIC

Combined direct-sun ultraviolet and infrared spectroscopies at Popocatépetl volcano (Mexico)

Volcanic plume composition is strongly influenced by both changes in magmatic systems and plume-atmosphere interactions. Understanding the degassing mechanisms controlling the type of volcanic activity implies deciphering the contributions of magmatic gases reaching the surface and their posterior chemical transformations in contact with the atmosphere. Remote sensing techniques based on direct solar absorption spectroscopy provide valuable information about most of the emitted magmatic gases but also on gas species formed and converted within the plumes. In this study, we explore the procedures, performances and benefits of combining two direct solar absorption techniques, high resolution Fourier Transform Infrared Spectroscopy (FTIR) and Ultraviolet Differential Optical Absorption Spectroscopy (UV-DOAS), to observe the composition changes in the Popocatépetl’s plume with high temporal resolution. The SO2 vertical columns obtained from three instruments (DOAS, high resolution FTIR and Pandora) were found similar (median difference <12%) after their intercalibration. We combined them to determine with high temporal resolution the different hydrogen halide and halogen species to sulfur ratios (HF/SO2, BrO/SO2, HCl/SO2, SiF4/SO2, detection limit of HBr/SO2) and HCl/BrO in the Popocatépetl’s plume over a 2.5-years period (2017 to mid-2019). BrO/SO2, BrO/HCl, and HCl/SO2 ratios were found in the range of (0.63 ± 0.06 to 1.14 ± 0.20) × 10−4, (2.6 ± 0.5 to 6.9 ± 2.6) × 10−4, and 0.08 ± 0.01 to 0.21 ± 0.01 respectively, while the SiF4/SO2 and HF/SO2 ratios were found fairly constant at (1.56 ± 0.25) × 10−3 and 0.049 ± 0.001. We especially focused on the full growth/destruction cycle of the most voluminous lava dome of the period that took place between February and April 2019. A decrease of the HCl/SO2 ratio was observed with the decrease of the extrusive activity. Furthermore, the short-term variability of BrO/SO2 is measured for the first time at Popocatépetl volcano together with HCl/SO2, revealing different behaviors with respect to the volcanic activity. More generally, providing such temporally resolved and near-real-time time series of both primary and secondary volcanic gaseous species is critical for the management of volcanic emergencies, as well as for the understanding of the volcanic degassing processes and their impact on the atmospheric chemistry.

Taquet, N.; Rivera Cárdenas, C.; Stremme, W.; Boulesteix, Thomas; Bezanilla, A.; Grutter, M.; García, O.; Hase, F.; Blumenstock, T.

Frontiers in Earth Science, 11: 1-18 (2023)

Chamigrane-Type Sesquiterpenes from Laurencia dendroidea as Lead Compounds against Naegleria fowleri

Naegleria fowleri is an opportunistic protozoon that can be found in warm water bodies. It is the causative agent of the primary amoebic meningoencephalitis. Focused on our interest to develop promising lead structures for the development of antiparasitic agents, this study was aimed at identifying new anti-Naegleria marine natural products from a collection of chamigrane-type sesquiterpenes with structural variety in the levels of saturation, halogenation and oxygenation isolated from Laurencia dendroidea. (+)-Elatol (1) was the most active compound against Naegleria fowleri trophozoites with IC50 values of 1.08 μM against the ATCC 30808™ strain and 1.14 μM against the ATCC 30215™ strain. Furthermore, the activity of (+)-elatol (1) against the resistant stage of N. fowleri was also assessed, showing great cysticidal properties with a very similar IC50 value (1.14 µM) to the one obtained for the trophozoite stage. Moreover, at low concentrations (+)-elatol (1) showed no toxic effect towards murine macrophages and could induce the appearance of different cellular events related to the programmed cell death, such as an increase of the plasma membrane permeability, reactive oxygen species overproduction, mitochondrial malfunction or chromatin condensation. Its enantiomer (−)-elatol (2) was shown to be 34-fold less potent with an IC50 of 36.77 μM and 38.03 μM. An analysis of the structure–activity relationship suggests that dehalogenation leads to a significant decrease of activity. The lipophilic character of these compounds is an essential property to cross the blood-brain barrier, therefore they represent interesting chemical scaffolds to develop new drugs.

Arberas-Jiménez, Íñigo; Nocchi, Nathália; Chao-Pellicer, Javier; Sifaoui, Ines; Ribeiro Soares, Angélica; DIAZ MARRERO, ANA RAQUEL ; Fernández, José J.; Piñero, José E.; Lorenzo-Morales, Jacob.

Marine Drugs, 21(4), 224: 1-14 (2023)

Meroterpenoids from Gongolaria abies-marina against Kinetoplastids: In Vitro Activity and Programmed Cell Death Study

Leishmaniasis and Chagas disease affect millions of people worldwide. The available treatments against these parasitic diseases are limited and display multiple undesired effects. The brown alga belonging to the genus Gongolaria has been previously reported as a source of compounds with different biological activities. In a recent study from our group, Gongolaria abies-marine was proven to present antiamebic activity. Hence, this brown alga could be a promising source of interesting molecules for the development of new antiprotozoal drugs. In this study, four meroterpenoids were isolated and purified from a dichloromethane/ethyl acetate crude extract through a bioguided fractionation process targeting kinetoplastids. Moreover, the in vitro activity and toxicity were evaluated, and the induction of programmed cell death was checked in the most active and less toxic compounds, namely gongolarone B (2), 6Z-1′-methoxyamentadione (3) and 1′-methoxyamentadione (4). These meroterpenoids triggered mitochondrial malfunction, oxidative stress, chromatin condensation and alterations of the tubulin network. Furthermore, a transmission electron microscopy (TEM) image analysis showed that meroterpenoids (2–4) induced the formation of autophagy vacuoles and ER and Golgi complex disorganization. The obtained results demonstrated that the mechanisms of action at the cellular level of these compounds were able to induce autophagy as well as an apoptosis-like process in the treated parasites.

San Nicolás-Hernández, Desirée; Rodríguez-Expósito, Rubén L.; López-Arencibia, Atteneri; Bethencourt-Estrella, Carlos J.; Sifaoui, Ines; Salazar-Villatoro, Lizbeth; Omaña-Molina, Maritza; Fernández, José J.; DIAZ MARRERO, ANA RAQUEL ; Piñero, José E.; Lorenzo-Morales, Jacob.

Pharmaceuticals, 16(4), 476: 1-20 (2023)

Editorial: Marine microalgae and biotoxins

Harmful algal blooms (HABs) and their impact in aquaculture, services and aquatic ecosystems in coastal areas are a major concern. The occurrence of these natural phenomena is expected to increase due to the growing pressure of anthropogenic activities, the projected climate trends, and their effects in the marine environment (Kazmi et al., 2022; Zhang et al., 2022). Methodological advances in monitoring systems for a fast and precise detection of biotoxins, together with a better knowledge on oceanographic conditions suitable for development of HABs, contributed to a more efficient and cost-effective management of aquaculture and fishery resources (Ruiz-Villarreal et al., 2022).

DIAZ MARRERO, ANA RAQUEL ; Fernandez, José J.; Rodríguez, Francisco; Band-Schmidt, Christine J.; Diogène, Jorge; Novelli, Antonello.

Frontiers in Marine Science, 10 (2023)

Comparative analysis of mycotoxin, pesticide, and elemental content of Canarian craft and Spanish mainstream beers

The number of craft breweries and the volume of craft beer produced globally is growing exponentially. However, little is known about their differences with mainstream beers regarding mycotoxin profile, pesticide and pollutant residues and elemental composition. Given that beer is one of the most consumed beverages worldwide, it is important to shed light on its toxicological profile. In this study, samples of 23 craft beers and 19 mainstream Spanish beers were collected to perform a comparative analysis including 8 mycotoxins, 225 pesticide residues and 50 POPs, and 50 elements. Mycotoxins were not detected in craft beers, while 100% of mainstream beers presented at least one mycotoxin. In contrast, craft beers contained higher average pesticide residues than their mainstream counterparts, although significant differences were only found in Mepiquat and Metrafenone content. No persistent organic pollutants were detected in any sample. The elemental composition presented differences between the two groups both in the concentration of elements and their hierarchy. In conclusion, the toxicological profile of all beers was safe and is unlikely to constitute a hazard to consumer health. Craft beers present significant differences from their mainstream counterparts in all the dimensions explored.

Alonso-González, Pablo; Parga-Dans, Eva; de las Heras Tranche, Iván; Acosta-Dacal, Andrea Carolina; Rodríguez Hernández, Ángel; Macías Montes, Ana; Zumbado Peña, Manuel; Pérez Luzardo, Octavio.

Toxicology Reports, 10: 389-399 (2023)

Control de la reactividad en plataformas moleculares multifuncionales y su aplicación a la construcción molecular orientada a la diversidad. Éteres propargílicos vinílicos como un caso de estudio

En este tutorial se muestra con el ejemplo de los éteres propargílicos vinílicos, bloques sintéticos multifuncionales, como es posible instrumentalizar la reactividad emergente de la combinación de sus grupos funcionales para el diseño y desarrollo de procesos dominó (cascada) ramificados para la generación de complejidad molecular orientada a la diversidad.

Tejedor, David; García-Tellado, Fernando.

Anales de química 119(1): 18-24 (2023)

Evolutionary genomics of oceanic island radiations

A recurring feature of oceanic archipelagos is the presence of adaptive radiations that generate endemic, species-rich clades that can offer outstanding insight into the links between ecology and evolution. Recent developments in evolutionary genomics have contributed towards solving long-standing questions at this interface. Using a comprehensive literature search, we identify studies spanning 19 oceanic archipelagos and 110 putative adaptive radiations, but find that most of these radiations have not yet been investigated from an evolutionary genomics perspective. Our review reveals different gaps in knowledge related to the lack of implementation of genomic approaches, as well as undersampled taxonomic and geographic areas. Filling those gaps with the required data will help to deepen our understanding of adaptation, speciation, and other evolutionary processes.

Cerca, José; Cotoras, Darko D.; Bieker, Vanessa C.; De-Kayne, Rishi; Vargas, Pablo; Fernández-Mazuecos, Mario; López-Delgado, Julia; White, Oliver; Stervander, Martin; Geneva, Anthony J.; Guevara Andino, Juan Ernesto; Meier, Joana Isabel; Roeble, Lizzie; Brée, Baptiste; Patiño, Jairo; Guayasamin, Juan M.; Torres, María de Lourdes; Valdebenito, Hugo; Castañeda María del Rosario; Chaves, Jaime A.; Jaramillo Díaz, Patricia; Valente, Luis; Knope, Matthew L.; Price, Jonathan P.; Rieseberg, Loren H.; Baldwin, Bruce G.; Emerson, Brent C.; Rivas-Torres, Gonzalo; Gillespie, Rosemary; Martin, Michael D.

Trends in Ecology & Evolution: 1-12 (2023)

Patterns and drivers of beta diversity across geographic scales and lineages in the Macaronesian flora

Aim: How spatial, historical and ecological processes drive diversity patterns remains one of the main foci of island biogeography. We determined how beta diversity varies across spatial scales and among organisms, disentangled the drivers of this variation, and examined how, consequently, biogeographic affinities within and among archipelagos vary among land plants.

Mouton, Lea; Patiño, Jairo; Carine, Mark; Rumsey, Fred; Menezes de Sequeira, Miguel; González-Mancebo, Juana María; de Almeida Gabriel, Rosalina Maria; Hardy, Olivier J.; Sim-Sim, Manuela; Reyes-Betancort, J. Alfredo; Collart, Flavien; Vanderpoorten, Alain.

Journal of biogeography, 0: 1-12 (2023)

Nano-biotechnology in tumour and cancerous disease: A perspective review

In recent years, drug manufacturers and researchers have begun to consider the nanobiotechnology approach to improve the drug delivery system for tumour and cancer diseases. In this article, we review current strategies to improve tumour and cancer drug delivery, which mainly focuses on sustaining biocompatibility, biodistribution, and active targeting. The conventional therapy using cornerstone drugs such as fludarabine, cisplatin etoposide, and paclitaxel has its own challenges especially not being able to discriminate between tumour versus normal cells which eventually led to toxicity and side effects in the patients. In contrast to the conventional approach, nanoparticle-based drug delivery provides target-specific delivery and controlled release of the drug, which provides a better therapeutic window for treatment options by focusing on the eradication of diseased cells via active targeting and sparing normal cells via passive targeting. Additionally, treatment of tumours associated with the brain is hampered by the impermeability of the blood–brain barriers to the drugs, which eventually led to poor survival in the patients. Nanoparticle-based therapy offers superior delivery of drugs to the target by breaching the blood–brain barriers. Herein, we provide an overview of the properties of nanoparticles that are crucial for nanotechnology applications. We address the potential future applications of nanobiotechnology targeting specific or desired areas. In particular, the use of nanomaterials, biostructures, and drug delivery methods for the targeted treatment of tumours and cancer are explored.

Soni, Ambikesh; Bhandari, Manohar Prasad; Tripathi, Gagan Kant; Bundela, Priyavand; Khiriya, Pradeep Kumar; Khare, Purnima Swarup; Kashyap, Manoj Kumar; Dey, Abhijit; Vellingiri, Balachandar; Sundaramurthy, Suresh; Suresh, Arisutha; Pérez de Lastra, José Manuel.

Journal of Cellular and Molecular Medicine: 1-26 (2023)

Drivers of consumer willingness to pay for sustainable wines: natural, biodynamic, and organic

This study analysed consumers’ willingness to pay (WTP) for wines with different sustainability features, namely natural, biodynamic, and organic, and explored the drivers of individual preferences for these wines. An online survey was conducted with a sample of 501 Italian regular wine consumers. To elicit WTP for natural, organic, and biodynamic wines, a multiple price list (MPL) was applied. The drivers of consumers’ preferences for the three wines were then investigated by means of a seemingly unrelated regression model (SUR). Results reveal a higher WTP for organic, followed by natural and biodynamic wines. The same core drivers of individual preferences were revealed for the three wine types: wine drinking frequency, naturalness perception, and wine health concerns. Wineries interested in commercialising sustainable wines should develop targeted communication campaigns to increase consumer awareness and understanding of the different sustainable production methods.

Vecchio, Riccardo; Annunziata, Azzurra; Parga-Dans, Eva; Alonso-González, Pablo.

Organic Agriculture: 1-14 (2023)