Esta sección incluye una lista de los últimos artículos científicos del IPNA publicados en revistas incluidas en el Science Citation Index (SCI).
En DIGITAL.CSIC, repositorio institucional del CSIC, pueden encontrar el listado completo de artículos científicos desde 1962, así como otras colecciones de interés como congresos, tesis, libros, material divulgativo, etc. del centro. El objetivo de DIGITAL.CSIC es organizar, preservar y difundir en acceso abierto los resultados de nuestra investigación.
En el repositorio institucional del CSIC, pueden encontrar el listado completo de artículos científicos, así como otras colecciones de interés como congresos, tesis, libros, material divulgativo, etc.
Análisis de la Producción Científica del IPNA 2014-2019: análisis bibliométrico realizado a partir de datos recogidos en Scopus y Web of Science.
The role of the brown bear Ursus arctos as a legitimate megafaunal seed disperser
Megafaunal frugivores can consume large amounts of fruits whose seeds may be dispersed over long distances, thus, affecting plant regeneration processes and ecosystem functioning. We investigated the role of brown bears (Ursus arctos) as legitimate megafaunal seed dispersers. We assessed the quantity component of seed dispersal by brown bears across its entire distribution based on information about both the relative frequency of occurrence and species composition of fleshy fruits in the diet of brown bears extracted from the literature. We assessed the quality component of seed dispersal based on germination experiments for 11 fleshy-fruited plant species common in temperate and boreal regions and frequently eaten by brown bears. Across its distribution, fleshy fruits, on average, represented 24% of the bear food items and 26% of the total volume consumed. Brown bears consumed seeds from at least 101 fleshy-fruited plant species belonging to 24 families and 42 genera, of which Rubus (Rosaceae) and Vaccinium (Ericaceae) were most commonly eaten. Brown bears inhabiting Mediterranean forests relied the most on fleshy fruits and consumed the largest number of species per study area. Seeds ingested by bears germinated at higher percentages than those from whole fruits, and at similar percentages than manually depulped seeds. We conclude that brown bears are legitimate seed dispersers as they consume large quantities of seeds that remain viable after gut passage. The decline of these megafaunal frugivores may compromise seed dispersal services and plant regeneration processes.
García-Rodríguez, Alberto; Albrecht; Jörg, Szczutkowska, Sylwia; Valido, Alfredo; Farwing, Nina; Selva, Nuria
Application of stimuli-responsive materials for extraction purposes
Stimuli-responsive materials, frequently designated as “smart/intelligent materials”, can modify their structure or properties by either a biological, physical, or chemical stimulus which, if properly controlled, could be used for specific applications. Such materials have been studied and exploited in several fields, like electronics, photonics, controlled drugs administration, imaging and medical diagnosis, among others, as well as in Analytical Chemistry where they have been used as chromatographic stationary phases, as part of sensors and for extraction purposes. This review article pretends to provide an overview of the most recent applications of these materials (mostly polymeric materials) in sample preparation for extraction purposes, as well as to provide a general vision of the current state-of-the-art of this field, their potential use and future applications.
González-Sálamo, Javier; Ortega-Zamora, Cecilia; Carrillo Fumero, Romen; Hernández-Borges, Javier
Polyoxygenated anti-inflammatory biscembranoids from the soft coral Sarcophyton tortuosum and their stereochemistry
Five novel biscembranoids, ximaolides H–L (1–5), along with four known related compounds (6–9) were isolated from the Hainan soft coral Sarcophyton tortuosum. The structures of the new compounds were determined by extensive spectroscopic analysis, quantum chemical calculations, and/or by comparing their CD spectra with those of the known compounds. Compounds 1 and 2 are the first examples of biscembranoids bearing a 1, 35-bridged lactone moiety, 4 is the first biscembranoid comprising an uncommon oxetane ring, and 5 represents the first 36-peroxyl biscembranoid. Ximaolides I (2), K (4) and F (9) exhibited interesting anti-inflammatory activity by the inhibition of LPS-induced TNF-α protein release in RAW264.7 macrophages.
Li, Yufen; Li, Songwei; Cuadrado, Cristina; Gao, Chenglong; Wu, Qihao; Li, Xiaolu; Pang, Tao; Hernández Daranas, Antonio; Guo, Yuewei; Li, Xuwen
First record of the carpenter bee Xylocopa pubescens (Hymenoptera, Apidae) in the Canary Islands confirmed by DNA barcoding
Island ecosystems are particularly vulnerable to the introduction of exotic species that can have an impact on local fauna and flora. Here, the carpenter bee Xylocopa pubescens is reported in Gran Canaria (Canary Islands, Spain) for the first time. This species is native to North Africa and the Near East and shows a rapid dispersion across the city of Las Palmas de Gran Canaria, together with a single record in the southernmost tip of the island. Different hypotheses about its arrival to the island are discussed.
Ruiz, Carlos; Suárez, Daniel; Naranjo, Manuel; De la Rúa, Pilar
Structure and Computational Basis for Backbone Rearrangement in Marine Oxasqualenoids
Six novel oxasqualenoids (polyether triterpenes) were isolated from the red alga Laurencia viridis. Laurokanols A–E (1–5) comprise an unreported tricyclic core with a [6,6]-spiroketal system. Yucatecone (6) shows a biogenetically intriguing epimerization at C14. Quantum mechanical calculations were used to corroborate their structures and to explain key steps involved in the biogenetic mechanisms proposed for the formation of oxasqualenoids.
Cen-Pacheco, Francisco; Santiago-Benítez, Adrián J.; Tsui, Ka Yi; Tantillo, Dean J.; Fernández, José J.; Hernández Daranas, Antonio
Pure Organic Active Compounds Against Abiotic Stress: A Biostimulant Overview
Biostimulants (BSs) are probably one of the most promising alternatives nowadays to cope with yield losses caused by plant stress, which are intensified by climatechange. Biostimulants comprise many different compounds with positive effects on plants, excluding pesticides and chemical fertilisers. Usually mixtures such as lixiviates from proteins or algal extracts have been used, but currently companies are interested in more specific compounds that are capable of increasing tolerance against abiotic stress. Individual application of a pure active compound offers researchers the opportunity to better standarise formulations, learn more about the plant defence process itself and assist the agrochemical industry in the development of new products. This review attempts to summarise the state of the art regarding various families of organic compounds and their mode/mechanism of action as BSs, and how they can help maximise agricultural yields under stress conditions aggravated by climate change.
García-García, Ana L.; García-Machado, Francisco J.; Borges, Andrés A.; Morales-Sierra, Sarai; Boto, Alicia; Jiménez-Arias, David
Building a global genomics observatory: Using GEOME (the Genomic Observatories Metadatabase) to expedite and improve deposition and retrieval of genetic data and metadata for biodiversity research
Genetic data represent a relatively new frontier for our understanding of global biodiversity. Ideally, such data should include both organismal DNA‐based genotypes and the ecological context where the organisms were sampled. Yet most tools and standards for data deposition focus exclusively either on genetic or ecological attributes. The Genomic Observatories Metadatabase (GEOME: geome‐db.org) provides an intuitive solution for maintaining links between genetic data sets stored by the International Nucleotide Sequence Database Collaboration (INSDC) and their associated ecological metadata. GEOME facilitates the deposition of raw genetic data to INSDCs sequence read archive (SRA) while maintaining persistent links to standards‐compliant ecological metadata held in the GEOME database. This approach facilitates findable, accessible, interoperable and reusable data archival practices. Moreover, GEOME enables data management solutions for large collaborative groups and expedites batch retrieval of genetic data from the SRA. The article that follows describes how GEOME can enable genuinely open data workflows for researchers in the field of molecular ecology.
Riginos, Cynthia; Crandall, Eric D.; Liggins, Libby; Gaither, Michelle R.; Ewing, Rodney B.; Meyer, Christopher; Andrews, Kimberly R.; Euclide, Peter T.; Titus, Benjamin M.; Therkildsen, Nina Overgaard; Salces-Castellano, Antonia; Stewart, Lucy C.; Toonen, Robert J.; Deck, John
Non‐apoptotic caspase activation preserves Drosophila intestinal progenitor cells in quiescence
Caspase malfunction in stem cells often precedes the appearance and progression of multiple types of cancer, including human colorectal cancer. However, the caspase‐dependent regulation of intestinal stem cell properties remains poorly understood. Here, we demonstrate that Dronc, the Drosophila ortholog of caspase‐9/2 in mammals, limits the number of intestinal progenitor cells and their entry into the enterocyte differentiation programme. Strikingly, these unexpected roles for Dronc are non‐apoptotic and have been uncovered under experimental conditions without epithelial replenishment. Supporting the non‐apoptotic nature of these functions, we show that they require the enzymatic activity of Dronc, but are largely independent of the apoptotic pathway. Alternatively, our genetic and functional data suggest that they are linked to the caspase‐mediated regulation of Notch signalling. Our findings provide novel insights into the non‐apoptotic, caspase‐dependent modulation of stem cell properties that could improve our understanding of the origin of intestinal malignancies.
Arthurton, Lewis; Nahotko, Dominik A.; Alonso, Jana; Wendler, Franz; Baena-López, Luis A.
El Vino “Natural”: Alimento, Cultura, Tradición, Patrimonio y… ¡Salud!
Según la Ley de la Viña y el Vino, éste “es el alimento natural obtenido exclusivamente por fermentación alcohólica, total o parcial, de uva fresca, estrujada o no, de mosto de uva” (Art. 2 Ley 24/2003, Gobierno de España). La RAE, en su séptima acepción de “natural” como adjetivo, define aquello “Que se produce por solas las fuerzas de la naturaleza, como contrapuesto a sobrenatural y milagroso”. Por tanto, la relación entre vino y alimento queda establecida en el marco normativo y definitorio español. Sin embargo, el vino continúa siendo el único producto alimentario no sujeto a regulación de etiquetado en cuanto a ingredientes y aditivos en todo el mundo. Ante esta tesitura comenzamos nuestra línea de investigación sobre vino, patrimonio, alimentación y salud, preguntándonos: ¿es sano/insano cualquier vino independientemente de su proceso productivo y propiedades organolépticas?, ¿son estos factores tenidos en cuenta en la certificación de la calidad del vino? La respuesta inmediata es que es imposible saberlo. ¿Cuáles son las consecuencias de esta situación anómala, y qué podemos hacer desde la investigación aplicada?
Parga-Dans, Eva; Alonso-González, Pablo
Protective effects of culture extracts (CB08035-SCA and CB08035-SYP) from Marinobacter hydrocarbonoclasticus (strain CB08035) against oxidant-induced stress in human colon carcinoma Caco-2 cells
The present study investigated the effect of culture extracts (CB08035-SCA and CB08035-SYP) from Marinobacter hydrocarbonoclasticus (strain CB08035) on cell viability and the potential protective effects attributed to molecular mechanisms underlying antioxidant response to survive oxidative stress injuries. Caco-2 cells were submitted to oxidative stress by treatment with tert-butyl hydroperoxide (t-BOOH). Both extracts prevented cell damage and enhanced activity of antioxidant defenses (NQO1 and GST activities and GSH levels) reduced by treatment with t-BOOH. Increased ROS and caspase 3/7 activity induced by t-BOOH were dose-dependently prevented when cells were treated with the extracts. CB08035-SCA caused up-regulation of Nrf2, AKT1 and Bcl-2 gene expressions. Moreover, CB08035-SCA and CB08035-SYP treatments reduced significantly Bax, BNIP3, APAF1, ERK1, JNK1, MAPK1, NFκB1, TNFα, IL-6, IL-1β and HO-1 gene expressions of apoptosis, proinflammation and oxidative stress induced by t-BOOH. CB08035-SCA and CB08035-SYP CPE extracts confer a significant protection against oxidative insults to cells. Our results show that culture extracts CB08035-SCA and CB08035-SYP from M. hydrocarbonoclasticus (strain CB08035) appeared to have antioxidant potential, based on their ability to protect antioxidant enzymes and mRNA gene expressions linked to apoptosis/oxidative pathways. These results suggest that culture extracts CB08035-SCA and CB08035-SYP can be a potential ingredient in the pharmaceutical and cosmeceutical industries.
Martínez, María-Aránzazu; Ares, Irma; Martínez, Marta; López-Torres, Bernardo; Rodríguez, José-Luis; Maximiliano, Jorge-Enrique; Martínez-Larrañaga, María-Rosa; Anadón, Arturo; de la Rosa, José-Manuel; Cueto, Mercedes
Cryptic differentiation in the Manx Shearwater hinders the identification of a new endemic subspecies
The taxonomy of Procellariiformes, particularly petrels and shearwaters, is still unresolved. The Manx shearwater Puffinus puffinus is one of the best studied seabirds worldwide. Most of the information known on this seabird is focused on the northern core populations where the species is abundant. However, the species shows a high number of peripheral populations, which are extremely small and difficult to study in comparison to central populations. Using an integrative approach, we provided significant evidence of phenological, morphological, acoustic, plumage colour, and genetic differentiation of the Canarian Manx shearwaters (the most southern population) from the northern breeding colonies, which is compatible with a long period of isolation. Birds from the Canary Islands breed around 2‐3 months earlier, are smaller and lighter, and show darker underwing plumage than those from northern populations. In addition, Canarian call features are different from the northern populations. Finally, genetic analyses of the mitochondrial control region indicate an incipient genetic differentiation of Canarian Manx shearwaters from the other breeding populations. The Canarian population holds a small number of breeding colonies and it is declining, so accurate taxonomic recognition critically affects conservation efforts. For all the aforementioned reasons, we propose to rank the Canarian breeding population as a new taxon by presenting the formal description of a new subspecies Puffinus puffinus canariensis ssp. nova.
Rodríguez, Airam; Rodríguez, Beneharo; Montelongo, Tinguaro; García-Porta, Joan; Pipa, Tania; Carty, Martin; Danielsen, Jóhannis; Nunes, Joâo; Silva, Carlos; Geraldes, Pedro; Medina, Félix M.; Illera, Juan Carlos
Saharan Dust Events in the Dust Belt -Canary Islandsand the Observed Association with in-Hospital Mortality of Patients with Heart Failure
Recent studies have found increases in the cardiovascular mortality rates during poor air quality events due to outbreaks of desert dust. In Tenerife, we collected (2014–2017) data in 829 patients admitted with a heart failure diagnosis in the Emergency Department of the University Hospital of the Canaries. In this region, concentrations of PM10 and PM2.5 are usually low (~20 and 10 g/m3), but they increase to 360 and 115 g/m3, respectively, during Saharan dust events. By using statistical tools (including multivariable logistic regressions), we compared in-hospital mortality of patients with heart failure and exposure to PM10 and PM2.5 during dust and no-dust events. We found that 86% of in-hospital heart failure mortality cases occurred during Saharan dust episodes that resulted in PM10 > 50 g/m3 (interquartile range: 71–96 g/m3). A multivariate analysis showed that, after adjusting for other covariates, exposure to Saharan dust events associated with PM10 > 50 g/m3 was an independent predictor of heart failure in-hospital mortality (OR = 2.79, 95% CI (1.066–7.332), p = 0.03). In conclusion, this study demonstrates that exposure to high Saharan dust concentrations is independently associated with in-hospital mortality in patients with heart failure.
Dominguez-Rodriguez, Alberto; Baez-Ferrer, Néstor; Rodríguez, Sergio; Avanzas, Pablo; Abreu-Gonzalez, Pedro; Terradellas, Enric; Cuevas, Emilio; Basart, Sara
O Antipatrimónio: Fetichismo do Passado e Dominação do Presente
O património é hoje uma palavra na boca de todos. Foi criado por nações e instituições, estudado por intelectuais e cientistas, criticado pela sua capacidade de gerar conflitos em relação à identidade e à memória. Tem sido mercantilizado globalmente com base em critérios semelhantes, da Tailândia à Bolívia. Mas essas investigações partiram principalmente do pressuposto de que o património é algo dado, bom e valioso em si mesmo e que sempre existiu. Por isso, o conceito de património não tem sido questionado como categoria, ou seja, como forma de relação própria das sociedades fetichistas e, portanto, historicamente determinada e com raízes histórico-culturais intrinsecamente ligadas ao surgimento e expansão do capitalismo e à epistemologia do iluminismo, moderna e ocidental. Este livro propõe uma crítica à categoria «património» a partir de uma etnografia da região de Maragatería, Espanha. A etnografia analisa empiricamente as transformações e processos que levam, ou não, o património a existir entre os maragatos.
Long‐term cloud forest response to climate warming revealed by insect speciation history
Montane cloud forests are areas of high endemism, and are one of the more vulnerable terrestrial ecosystems to climate change. Thus, understanding how they both contribute to the generation of biodiversity, and will respond to ongoing climate change, are important and related challenges. The widely accepted model for montane cloud forest dynamics involves upslope forcing of their range limits with global climate warming. However, limited climate data provides some support for an alternative model, where range limits are forced downslope with climate warming. Testing between these two models is challenging, due to the inherent limitations of climate and pollen records. We overcome this with an alternative source of historical information, testing between competing model predictions using genomic data and demographic analyses for a species of beetle tightly associated to an oceanic island cloud forest. Results unequivocally support the alternative model: populations that were isolated at higher elevation peaks during the Last Glacial Maximum are now in contact and hybridizing at lower elevations. Our results suggest that genomic data are a rich source of information to further understand how montane cloud forest biodiversity originates, and how it is likely to be impacted by ongoing climate change.
Salces-Castellano, Antonia; Stankowski, Sean; Arribas, Paula; Patiño, Jairo; Karger Dirk N.; Butlin, Roger; Emerson, Brent C.
Tandem Radical Fragmentation/Cyclization of Guanidinylated Monosaccharides Grants Access to Medium-Sized Polyhydroxylated Heterocycles
The fragmentation of anomeric alkoxyl radicals (ARF) and the subsequent cyclization promoted by hypervalent iodine provide an excellent method for the synthesis of guanidino-sugars. The methodology described herein is one of the few existing general methodologies for the formation of medium-sized exo- and endoguanidine-containing heterocycles presenting a high degree of oxygenation in their structure.
Santana, Andrés G.; González Martín, Concepción C.
Coumarins and other constituents from Deverra battandieri
Three undescribed coumarin derivatives, pituranthosin A–C (1-3), along with nineteen known compounds were isolated and identified from the chloroform and ethyl acetate fractions of the hydroalcoholic extract of Deverra battandieri (Apiaceae). The structures of the compounds were established by interpretation of their spectral data using 1D-NMR (1H, 13C, DEPT experiments), 2D-NMR (COSY, NOESY, HSQC and HMBC), HRESIMS, and by comparison with the literature data.
Esseid, Chahrazed; León, Francisco; Mosset, Paul; Benayache, Samir; Marchioni, Eric; Brouard, Ignacio; Benayache, Fadila