Publicaciones

The emergence of drug-resistant bacteria poses a significant challenge to modern medicine. In response, Artificial Intelligence (AI) and Machine Learning (ML) algorithms have emerged as powerful tools for combating antimicrobial resistance (AMR). This review aims to explore the role of AI/ML in AMR management, with a focus on identifying pathogens, understanding resistance patterns, predicting treatment outcomes, and discovering new antibiotic agents. Recent advancements in AI/ML have enabled the efficient analysis of large datasets, facilitating the reliable prediction of AMR trends and treatment responses with minimal human intervention. ML algorithms can analyze genomic data to identify genetic markers associated with antibiotic resistance, enabling the development of targeted treatment strategies. Additionally, AI/ML techniques show promise in optimizing drug administration and developing alternatives to traditional antibiotics. By analyzing patient data and clinical outcomes, these technologies can assist healthcare providers in diagnosing infections, evaluating their severity, and selecting appropriate antimicrobial therapies. While integration of AI/ML in clinical settings is still in its infancy, advancements in data quality and algorithm development suggest that widespread clinical adoption is forthcoming. In conclusion, AI/ML holds significant promise for improving AMR management and treatment outcome.

Martins, Anabela; Collart, Flavien; Sim-Sim, Manuela; Patiño, Jairo.

Ciguateric syndrome is a food poisoning associated with the consumption of some species of fish that have accumulated ciguatoxins (CTXs) in their tissues. The effects of the syndrome occur with nervous imbalances which have been described for quite some time, and mentioned in sailing literature for centuries. In the last decade, research has been focused on the implementation of analytical methods for toxin identification and the study of action modes of CTXs to design effective treatments. However, an important aspect is to determine the damage that CTXs caused in the organs of affected individuals. In this work, the damages observed in tissues of mice, mainly in the small intestine, were analyzed. The animals were fed with CTX-contaminated fish muscle at concentrations 10-times below the median lethal dose (LD50) for 10 weeks. The analysis of tissues derived from the oral treatment resulted in an increased occurrence of Paneth cells, presence of lymphoid tissue infiltrating the mucosa and fibrous lesions in the mucosal layer of the small intestine. A decreasing weight in animals fed with toxic muscle was observed.

Interferometric Synthetic Aperture Radar (InSAR) has catapulted our ability to detect, quantify, and characterize bio- and geophysical processes (e.g., aquifer dynamics, tectonic, and magmatic processes, etc.). During the last four decades, InSAR has imaged the complete Earth’s land surface and transformed our understanding of how Earth works. Such revolution has been underpinned by a relentless development of radar technology and processing methods and facilitated by free and open access to satellite missions’ data. Although satellite radar images represent electrical and geometrical properties of the illuminated ground surface, here I focus on the geometric information obtained from the phase delay (interferometric) patterns between two or more SAR images. After a brief overview of InSAR history, I review the fundamentals of the most popular interferometric methods and present a vision of how InSAR will deliver wide and easily accessible global high-resolution processed information, highlighting future challenges to monitor and understand Earth dynamics. Finally, I encourage further work on developing new radar mission concepts and harnessing big-data processing workflows deployed on energy-efficient and fast computing infrastructure, while minimizing our environmental footprint. To achieve such ambitious goals, I argue that researchers and technicians will have to collaborate in an inclusive environment, with a wide and diverse range of beneficiaries to achieve sustainability on a fast-changing Earth.

The Canary Islands is a Macaronesian volcanic archipelago with a depauperate community of three species of Kalotermitidae, including Kalotermes dispar. A total of 54 Kalotermes colonies were collected from Gran Canaria, Tenerife, La Gomera, La Palma, and El Hierro islands. Soldiers and imagos were morphologically examined and sequenced for four mitochondrial markers. Although morphological differences could not be detected, phylogenetic analysis of both cox1/tRNA/cox2 and rrnL markers revealed two distinct clades of K. dispar, suggesting cryptic diversity. The diversification within the Canary Kalotermes lineage most likely occurred around 7.5 Mya, while the divergence within the two clades was reconstructed at about 3.6 Mya and 1.9 Mya. Kalotermes approximatus from the southeastern Nearctic constitutes a sister to the Canary Kalotermes, while the Palearctic K. flavicollis, K. italicus, and K. phoenicae form a separate clade. It is hypothesized that a faunal exchange of Kalotermes from the Nearctic to the Canary Islands occurred via transoceanic rafting during the mid-Miocene.

Background

Current trends in Analytical Chemistry are highly focused on the introduction of new extraction materials with a high selectivity towards the target analytes, high extraction capacity as well as sustainable characteristics. In this context, the introduction of smart materials able to respond to an external stimulus constitutes a promising approach in the field. However, investigations regarding the development of such stimuli-responsive polymers have been basically centered on their synthesis and the control of their properties, and hardly on exploiting such properties to generate polymers that, once their extraction function is fulfilled, they can be degraded into fragments with little or negligible toxicity, or even into their constituent monomers for an efficient recycling.

Results

The applicability of a degradable and recyclable dynamic covalent polymer based on the use of tetrazine as a linker was assessed as sorbent for the extraction of a group of 37 persistent organic pollutants, including 10 polycyclic aromatic hydrocarbons, 11 organochlorine pesticides, 14 polychlorinated biphenyls, and 2 antibacterial agents, from water samples. A microdispersive solid-phase extraction procedure was developed for the selective extraction of the target analytes, while their separation, determination, and quantification were achieved by gas chromatography coupled to mass spectrometry. The optimized procedure was validated for seawater and wastewater obtaining mean relative recovery values between 72 and 112 % for almost all the analytes, with satisfactory relative standard deviation values (<18 %). After extraction, the polymer could be degraded by adding the amino acid L-tyrosine, being possible a quantitative recovery of the initial functional monomer.

Significance

A responsive polymer based on the chemical versatility of the tetrazine ring was used as sorbent in sample preparation providing excellent results, showing good physicochemical properties and the ability to be degraded after use. This polymer constitutes an interesting alternative to reduce chemical waste through the recycling of monomers, contributing to the development of more sustainable analytical methodologies.

This article provides an overview of the development, structure and activity of various metal complexes with anti-cancer activity. Chemical researchers continue to work on the development and synthesis of new molecules that could act as anti-tumor drugs to achieve more favorable therapies. It is therefore important to have information about the various chemotherapeutic substances and their mode of action. This review focuses on metallodrugs that contain a metal as a key structural fragment, with cisplatin paving the way for their chemotherapeutic application. The text also looks at ruthenium complexes, including the therapeutic applications of phosphorescent ruthenium(II) complexes, emphasizing their dual role in therapy and diagnostics. In addition, the antitumor activities of titanium and gold derivatives, their side effects, and ongoing research to improve their efficacy and reduce adverse effects are discussed. Metallization of host defense peptides (HDPs) with various metal ions is also highlighted as a strategy that significantly enhances their anticancer activity by broadening their mechanisms of action.

The brown bear reintroduction program in the Pyrenees was launched in 1996, once their population was considered extinct in the central parts of the mountain range. The increasing number of livestock casualties caused by bear attacks forced the public administrations to adopt a package of protection measures, which included hiring mountain shepherds to tend the local farmers' flocks during the summer grazing season. Although these measures were deemed to restore age-old communal shepherding practices that had recently been abandoned by bringing together bears, livestock, and shepherds in the high mountain pastures, the bear program has produced an overlap of communal and state-driven territorialities. Drawing attention to the ambiguous position of mountain shepherds within a new pastoralism-conservation network, situated between local farmers and bear program's decision-makers, this article argues that the commons must be taken into consideration as it persists in current times, even within a high-modern territoriality unfolded under different forms of environmentality. The shepherds epitomize the hybridization of different territorialities, situated on the edge of the production-based economy developed by the local farmers and the amenity-based economy behind the bear reintroduction program. There is a shared, though differentiated capitalist view of natural resources. Using the main theories of power in political ecology and taking the variables of 'format, management, governance, and institution' to frame the commons as an enduring local collective farming resource, this article scrutinizes the collision between the two types of capitalism, usually misidentified as a rural-urban divide. It also shows the extent to which the shifting existence of the commons, crystallized through the ambiguous position of the shepherds, may provide us with a fruitful toolkit to better understanding human-wildlife conflicts based on the cleavage between farming and conservationist sectors.

Los animales son parte constitutiva de la vida humana, del mismo modo que nosotros, como animales humanos, pertenecemos de una u otra forma a sus mundos. Es difícil imaginar cómo podríamos definirnos o identificarnos como humanos si no es junto a otros animales. Los estudios humano- animales, un campo académico que ha crecido exponencialmente en las dos últimas décadas, abordan la diversidad de estas relaciones para comprender cómo las imaginamos, experimentamos y, en definitiva, nos dan forma. Este nuevo «giro» en la antropología tensiona tanto el objeto, el método y la representación en la disciplina, como los pilares del proyecto humanista sobre el que se construyó, renovando el interés sobre conceptos como la relación, la agencia, la personalidad, o lo humano, pero también sobre las densas tramas que nos anudan con la historia, el lenguaje, la política, la sociedad o la cultura. Esta tarea requiere una mirada que vaya «más allá de lo humano» y se interese por las influencias y cuidados mutuos, las asimetrías, los vínculos afectivos y las violencias que marcan la convivencia con otros seres. En ese empeño, este volumen presenta quince historias entre humanos y animales que se dan a lo largo y ancho del Estado español. Todas ellas exploran caminos donde las contingencias, los desafíos, los problemas y los devenires no son solo humanos, y donde una diversidad de criaturas (perdices, gallos, atunes, toros, gatos, perros, osos, lobos, ovejas, caballos, vacas, cabras, cerdos, jabalíes o primates, entre otros) muestran su alteridad en la conformación de los mundos sociales.

We describe the hitherto unknown male of Centromerus fuerteventurensis Wunderlich, 1992 and present new illustrations of the epigyne and vulva. We also provide an update on the known distribution of this species on the Canary Islands.