Esta sección incluye una lista de los últimos artículos científicos del IPNA publicados en revistas incluidas en el Science Citation Index (SCI).
En DIGITAL.CSIC, repositorio institucional del CSIC, pueden encontrar el listado completo de artículos científicos desde 1962, así como otras colecciones de interés como congresos, tesis, libros, material divulgativo, etc. del centro. El objetivo de DIGITAL.CSIC es organizar, preservar y difundir en acceso abierto los resultados de nuestra investigación.
En el repositorio institucional del CSIC, pueden encontrar el listado completo de artículos científicos, así como otras colecciones de interés como congresos, tesis, libros, material divulgativo, etc.
Análisis de la Producción Científica del IPNA 2014-2019: análisis bibliométrico realizado a partir de datos recogidos en Scopus y Web of Science.
The social value of heritage: Balancing the promotion-preservation relationship in the Altamira World Heritage Site, Spain
The designation of World Heritage Sites (WHSs) by UNESCO strengthens the international and national image of heritage destinations in the growing market of cultural tourism. Understanding how different stakeholders interpret the value of cultural heritage is one of the most important assets for balancing the promotion and protection of WHSs. This study draws on the case of the Altamira Prehistoric Cave WHS (Spain), whose preservation is under threat and constant debate. It explores factors determining the social value of heritage, namely: existence, aesthetic, economic, and legacy value. In doing so, this paper contributes to emerging debates on heritage management and tourist destinations. Data were collected using two surveys, one focused on visitors, with a total of 1047 valid surveys, and another on the Spanish population as a WHS host community, with a total of 1000 valid surveys. The analysis of these surveys shows how the existence, aesthetic, economic and legacy value dimensions of cultural heritage can build up brands around WHSs. The social-value dimension of cultural heritage therefore affects the market potential of WHSs, whose market potential is closely related to the education levels of a given society. These findings provide valuable information and insights for academics, destination managers and policy-makers in the debate about the preservation and tourism branding of Altamira. This will allow different stakeholders to identify opportunities to develop synergies between tourism promotion and heritage preservation, to both strengthen the brand image of a WHS and preserve its heritage.
Parga-Dans, Eva; Alonso-González, Pablo; Otero Enríquez, Raimundo
Species functional traits and abundance as drivers of multiplex ecological networks: first empirical quantification of inter-layer edge weights
Many vertebrate species act as both plant pollinators and seed-dispersers, thus interconnecting these processes, particularly on islands. Ecological multilayer networks are a powerful tool to explore interdependencies between processes; however, quantifying the links between species engaging in different types of interactions (i.e. inter-layer edges) remains a great challenge. Here, we empirically measured inter-layer edge weights by quantifying the role of individually marked birds as both pollinators and seed-dispersers of Galápagos plant species over an entire year. Although most species (80%) engaged in both functions, we show that only a small proportion of individuals actually linked the two processes, highlighting the need to further consider intra-specific variability in individuals' functional roles. Furthermore, we found a high variation among species in linking both processes, i.e. some species contribute more than others to the modular organization of the multilayer network. Small and abundant species are particularly important for the cohesion of pollinator seed-dispersal networks, demonstrating the interplay between species traits and neutral processes structuring natural communities.
Hervías-Parejo, Sandra; Tur, Carmen; Heleno, Rubén; Nogales, Manuel; Timóteo, Sérgio; Travaser, Anna
Food habits of the Macaronesian Sparrowhawk (Accipiter Nisus Granti) on Madeira
The Eurasian Sparrowhawk (Accipiter nisus) is a small bird of prey distributed throughout Europe and Asia and closely linked to forest environments. It is a predator of a wide diversity of prey, primarily birds (Newton et al. 1986). On the mainland, the male Eurasian Sparrowhawk typically captures small birds (40–120 g in mass), whereas females (nearly twice the mass of males) prey on larger birds (up to 500 g; Opdam 1975, Newton 1978).
González, Yolanda; Hervías-Parejo, Sandra; Pereira, Estefanía; Vulcano, Antonio; Álvarez, Soledad; Gouveia, Cátia; Nunes, Marta; Castelló, Laura; Fagundes, Isabel; Coelho, Nádia; Delgado, Guillermo, Nogales, Manuel
Prorocentroic Acid, a Neuroactive Super-Carbon-Chain Compound from the Dinoflagellate Prorocentrum hoffmannianum
Prorocentroic acid (PA) was isolated from the dinoflagellate Prorocentrum hoffmannianum. Relative configurations for its 35 asymmetric centers, were determined by analysis of NMR data including heteronuclear couplings and quantum mechanical calculations. PA was tested by using murine cortical neurons grown on microelectrode-arrays. Long term exposure to subtoxic concentrations induced a significant reorganization of neuronal signaling, mainly by changes in the bursting activity. The observed effects could be due to the activation of a plasticity process.
Domínguez, Humberto J.; Cabrera-García, David; Cuadrado, Cristina; Novelli, Antonello; Fernández-Sánchez, M. Teresa; Fernández, José J.; Hernández Daranas, Antonio
El Vino “Natural”: Alimento, Cultura, Tradición, Patrimonio y… ¡Salud!
Según la Ley de la Viña y el Vino, éste “es el alimento natural obtenido exclusivamente por fermentación alcohólica, total o parcial, de uva fresca, estrujada o no, de mosto de uva” (Art. 2 Ley 24/2003, Gobierno de España). La RAE, en su séptima acepción de “natural” como adjetivo, define aquello “Que se produce por solas las fuerzas de la naturaleza, como contrapuesto a sobrenatural y milagroso”. Por tanto, la relación entre vino y alimento queda establecida en el marco normativo y definitorio español. Sin embargo, el vino continúa siendo el único producto alimentario no sujeto a regulación de etiquetado en cuanto a ingredientes y aditivos en todo el mundo. Ante esta tesitura comenzamos nuestra línea de investigación sobre vino, patrimonio, alimentación y salud, preguntándonos: ¿es sano/insano cualquier vino independientemente de su proceso productivo y propiedades organolépticas?, ¿son estos factores tenidos en cuenta en la certificación de la calidad del vino? La respuesta inmediata es que es imposible saberlo. ¿Cuáles son las consecuencias de esta situación anómala, y qué podemos hacer desde la investigación aplicada?
Parga-Dans, Eva; Alonso-González, Pablo
Protective effects of culture extracts (CB08035-SCA and CB08035-SYP) from Marinobacter hydrocarbonoclasticus (strain CB08035) against oxidant-induced stress in human colon carcinoma Caco-2 cells
The present study investigated the effect of culture extracts (CB08035-SCA and CB08035-SYP) from Marinobacter hydrocarbonoclasticus (strain CB08035) on cell viability and the potential protective effects attributed to molecular mechanisms underlying antioxidant response to survive oxidative stress injuries. Caco-2 cells were submitted to oxidative stress by treatment with tert-butyl hydroperoxide (t-BOOH). Both extracts prevented cell damage and enhanced activity of antioxidant defenses (NQO1 and GST activities and GSH levels) reduced by treatment with t-BOOH. Increased ROS and caspase 3/7 activity induced by t-BOOH were dose-dependently prevented when cells were treated with the extracts. CB08035-SCA caused up-regulation of Nrf2, AKT1 and Bcl-2 gene expressions. Moreover, CB08035-SCA and CB08035-SYP treatments reduced significantly Bax, BNIP3, APAF1, ERK1, JNK1, MAPK1, NFκB1, TNFα, IL-6, IL-1β and HO-1 gene expressions of apoptosis, proinflammation and oxidative stress induced by t-BOOH. CB08035-SCA and CB08035-SYP CPE extracts confer a significant protection against oxidative insults to cells. Our results show that culture extracts CB08035-SCA and CB08035-SYP from M. hydrocarbonoclasticus (strain CB08035) appeared to have antioxidant potential, based on their ability to protect antioxidant enzymes and mRNA gene expressions linked to apoptosis/oxidative pathways. These results suggest that culture extracts CB08035-SCA and CB08035-SYP can be a potential ingredient in the pharmaceutical and cosmeceutical industries.
Martínez, María-Aránzazu; Ares, Irma; Martínez, Marta; López-Torres, Bernardo; Rodríguez, José-Luis; Maximiliano, Jorge-Enrique; Martínez-Larrañaga, María-Rosa; Anadón, Arturo; de la Rosa, José-Manuel; Cueto, Mercedes
Synthesis of α,γ-peptide hybrids by selective conversion of glutamic acid units
Saavedra, Carlos J.; Boto, Alicia; Hernández, Rosendo
Towards a Structural Basis for the Relationship Between Blood Group and the Severity of El Tor Cholera
It has long been known that people with blood group O are more severely affected by El Tor cholera than those with blood groups A or B. Microcalorimetry and NMR spectroscopy are used to evaluate the ability of the B‐subunits of cholera toxin and E. coli heat‐labile toxin to bind to selected blood group oligosaccharides.
Mandal, Pintu K.; Branson, Thomas R.; Hayes, Edward D.; Ross, James F.; Gavín, José A.; Hernández Daranas, Antonio; Turnbull, W. Bruce
Major components of Spanish cultivated Artemisia absinthium populations: Antifeedant, antiparasitic, and antioxidant effects
The objective of this study was the valorization of Spanish Artemisia absinthium populations from Teruel (Aragón) and Sierra Nevada (Granada). These populations were experimentally cultivated in the field and under controlled conditions. Three major components were isolated from a two year-old population obtained from the Teruel population cultivated in Ejea-Zaragoza in 2003, and identified by NMR experiments as the sequiterpene lactone hydroxypelenolide (I) and the flavones artemetin (II) and casticin (III). The I–III content of the plant extracts was analyzed by HPLC-DAD. The insect antifeedant properties of plant extracts from different years and crops were tested against Spodoptera littoralis, Myzus persicae and Rhopalosiphum padi. Additionally we studied their antioxidant, phytotoxic and antiparasitic effects.
Gonzalez-Coloma, Azucena; Bailen, Maria; Diaz, Carmen E.; Fraga, Braulio M.; Martínez-Díaz, Rafael; Zuñiga, Gustavo E.; Contreras, Rodrigo A.; Cabrera, Raimundo; Burillo, Jesus
Supercritical CO2 extraction of Persea indica: Effect of extraction parameters, modelling and bioactivity of its extracts
The objective of the work was to optimize the extraction of Persea indica L. bioactive compounds by means of supercritical fluid extraction (SFE) and analyze their insecticidal effects. P. indica L. is one of the dominant species of the Canarian laurel forest, a relict of the Tertiary flora. Different extraction conditions (pressure, plant material particle size, temperature, CO2 flow) and the influence of entrainer were tested and the evolution of the extracted compounds was screened by HPLC–MS. A comparison with conventional techniques such as hydrodistillation (HD) or organic solvent extraction (OSE) was also presented. Particularly, four CO2 densities ranging from 628.61 kg/m3 to 839.81 kg/m3 were studied in the range of 10.0–20.0 MPa and 40–50 °C. The extracts contained insecticidal ryanodanes of great interest, previously described as insecticidal components of P. indica. The insecticidal antifeedant activity of selected extracts was inspected. A model based on mass transfer equations, the Sovová model, was successfully applied to correlate the experimental data.
Martín, L; González-Coloma, A.; Díaz, C. E.; Mainara, A. M.; Urieta, J. S.
A New Catalytic Prins Cyclization Leading to Oxa- and Azacycles
A new Prins cyclization process that builds up one carbon−carbon bond, one heteroatom-carbon bond, and one halogen-carbon bond, (in an oxa- and azacycle) relies on an iron catalyst system formed from Fe(acac)3 and trimethylsilyl halide. The method displays a broad substrate scope and is economical, environmentally friendly, and experimentally simple. This catalytic method permits the construction of chloro, bromo and iodo heterocycles, by the suitable combination of iron(III) source, the corresponding trimethylsilyl halide and the solvent, in high yields.
Miranda, Pedro O.; Carballo, Ruben M.; Martín, Víctor S.; Padrón, Juan I.
Molecular analysis of menadione-induced resistance against biotic stress in Arabidopsis
Menadione sodium bisulphite (MSB) is a water-soluble derivative of vitamin K3, or menadione, and has been previously demonstrated to function as a plant defence activator against several pathogens in several plant species. However, there are no reports of the role of this vitamin in the induction of resistance in the plant model Arabidopsis thaliana. In the current study, we demonstrate that MSB induces resistance by priming in Arabidopsis against the virulent strain Pseudomonas syringae pv. tomato DC3000 (Pto) without inducing necrosis or visible damage. Changes in gene expression in response to 0.2 mm MSB were analysed in Arabidopsis at 3, 6 and 24 h post-treatment using microarray technology. In general, the treatment with MSB does not correlate with other publicly available data, thus MSB produces a unique molecular footprint. We observed 158 differentially regulated genes among all the possible trends. More up-regulated genes are included in categories such as 'response to stress' than the background, and the behaviour of these genes in different treatments confirms their role in response to biotic and abiotic stress. In addition, there is an over-representation of the G-box in their promoters. Some interesting functions are represented among the individual up-regulated genes, such as glutathione S-transferases, transcription factors (including putative regulators of the G-box) and cytochrome P450s. This work provides a wide insight into the molecular cues underlying the effect of MSB as a plant resistance inducer.
Borges, Andrés A.; Dobón, Albor; Expósito Rodríguez, Marino; Jiménez Arias, David; Borges-Pérez, Andrés; Casañas-Sánchez, Verónica; Pérez Méndez, J. A.; Luis, Juan C.; Tornero, Pablo