Publications

This section includes a list of the latest IPNA scientific articles published in journals included in the Science Citation Index (SCI).

In DIGITAL.CSIC, institutional repository of the CSIC, you can find the complete list of scientific articles since 1962, as well as other collections of interest such as congresses, theses, books, informative material, etc. of the centre. The aim of DIGITAL.CSIC is to organize, preserve and disseminate in open access the results of our research.

In the institutional repository of the CSIC, you can find the complete list of scientific articles, as well as other collections of interest such as congresses, theses, books, informative material, etc.

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Analysis of the IPNA 2014-2019 Scientific Production: bibliometric analysis from data collected in Scopus and Web of Science.

 

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Photocatalytic active polymers in organic synthesis

The idea of using covalently bonded photocatalysts (PCs) on polymers or photocatalytic active polymers originated from the need of recyclable catalysts for the transition from photocatalysis in laboratories to industry scale. Compared with commonly used iridium or ruthenium complexes, metal-free polymers are low cost, stable, efficient, and recyclable catalysts. The development of metal-free photocatalytic active, metal-photosensitizer bonded, photosensitizer-cross-linked, and surface-immobilized polymer-supported PCs are discussed in this chapter through respective examples.

Abramov, Alex; Díaz Díaz, David

Smart Polymer Catalysts and Tunable Catalysis: 177-208 (2019)
DOIDigital.CSIC

Antiprotozoal activities of marine polyether triterpenoids

Chagas disease and leishmaniasis are tropical neglected diseases caused by kinetoplastids protozoan parasites of Trypanosoma and Leishmania genera, and a public health burden with high morbidity and mortality rates in developing countries. Among difficulties with their epidemiological control, a major problem is their limited and toxic treatments to attend the affected populations; therefore, new therapies are needed in order to find new active molecules. In this work, sixteen Laurencia oxasqualenoid metabolites, natural compounds 1–11 and semisynthetic derivatives 12–16, were tested against Leishmania amazonensis, Leishmania donovani and Trypanosoma cruzi. The results obtained point out that eight substances possess potent activities, with IC values in the range of 5.40–46.45 µM. The antikinetoplastid action mode of the main metabolite dehydrothyrsiferol (1) was developed, also supported by AFM images. The semi-synthetic active compound 28-iodosaiyacenol B (15) showed an IC 5.40 µM against Leishmania amazonensis, turned to be non-toxic against the murine macrophage cell line J774A.1 (CC > 100). These values are comparable with the reference compound miltefosine IC 6.48 ± 0.24 and CC 72.19 ± 3.06 μM, suggesting that this substance could be scaffold for development of new antikinetoplastid drugs.

Díaz-Marrero, Ana R. ; López-Arencibia, Atteneri; Bethencout-Estrella, Carlos J.; Cen-Pacheco, Francisco; Sifaoui, Ines; Hernández Creus, Alberto; Duque-Ramírez, María Clara; Souto, María L.; Hernández Daranas, Antonio ; Lorenzo-Morales, Jacob; Piñero, José E.; Fernández, José J.

Bioorganic Chemistry 92: 103276 (2019)
DOIDigital.CSIC

Environmental temperatures shape thermal physiology as well as diversification and genome-wide substitution rates in lizards

Climatic conditions changing over time and space shape the evolution of organisms at multiple levels, including temperate lizards in the family Lacertidae. Here we reconstruct a dated phylogenetic tree of 262 lacertid species based on a supermatrix relying on novel phylogenomic datasets and fossil calibrations. Diversification of lacertids was accompanied by an increasing disparity among occupied bioclimatic niches, especially in the last 10 Ma, during a period of progressive global cooling. Temperate species also underwent a genome-wide slowdown in molecular substitution rates compared to tropical and desert-adapted lacertids. Evaporative water loss and preferred temperature are correlated with bioclimatic parameters, indicating physiological adaptations to climate. Tropical, but also some populations of cool-adapted species experience maximum temperatures close to their preferred temperatures. We hypothesize these species-specific physiological preferences may constitute a handicap to prevail under rapid global warming, and contribute to explaining local lizard extinctions in cool and humid climates.

Garcia-Porta, Joan; Irisarri, Iker; Kirchner, Martin; Rodríguez, Ariel; Kirchhof, Sebastian; et al.

Nature Communications 10: 4077 (2019)
DOIDigital.CSIC

Geochemical signals related to the 2011–2012 El Hierro submarine eruption

On 10 October 2011, a submarine volcanic eruption began 2 km south of the island of El Hierro (Canary Islands, Spain). It was the first eruption after 40 years of quiescence in the Canarian archipelago. Since mid-July 2011, a multiparametric network has been deployed by the Instituto Geográfico Nacional (hereinafter IGN)to monitor volcanic processes. The data recorded by five stations, measuring the air and soil temperature, CO and radon concentration in the air inside four galleries and one well, are the focus of the present paper. Two important anomalies were found that improve comprehension of the volcanic process. First, a clear increase in CO concentration in one gallery (from 825 ± 19 to 2305 ± 35 ppm)which seems to be mainly controlled by ground deformation measured during the unrest period preceding the eruption. Second, a relationship between radon concentration in air in a well located in the northern side of the island with seismic energy release (several peaks with up to 115% increase), and ground deformation (50% growth in background level), also before the eruption onset. Lastly, changes in radon concentration during eruptive period seem to be modulated by seismic activity (increases up to 233%), which in turn is likely related to variations in magma rheology.

Torres-González, Pedro; Moure-García, David; Luengo-Oroz, Natividad; Villasante-Marcos, Victor; Iribarren, Ilaskiñe; Blanco, M. José; Soler, Vicente ; Jiménez-Abizanda, García-Fraga, José

Journal of Volcanology and Geothermal Research 381: 32-43 (2019)
DOIDigital.CSIC

Chance and predictability in evolution: The genomic basis of convergent dietary specializations in an adaptive radiation

The coexistence of multiple eco-phenotypes in independently assembled communities makes island adaptive radiations the ideal framework to test convergence and parallelism in evolution. In the radiation of the spider genus Dysdera in the Canary Islands, species diversification occurs concomitant with repeated events of trophic specialization. These dietary shifts, to feed primarily on woodlice, are accompanied by modifications in morphology (mostly in the mouthparts), behaviour and nutritional physiology. To gain insight into the molecular basis of this adaptive radiation, we performed a comprehensive comparative transcriptome analysis of five Canary Island Dysdera endemics representing two evolutionary and geographically independent events of dietary specialization. After controlling for the potential confounding effects of hemiplasy, our differential gene expression and selective constraint analyses identified a number of genetic changes that could be associated with the repeated adaptations to specialized diet of woodlice, including some related to heavy metal detoxification and homeostasis, the metabolism of some important nutrients and venom toxins. Our results shed light on the genomic basis of an extraordinary case of dietary shift convergence associated with species diversification. We uncovered putative molecular substrates of convergent evolutionary changes at different hierarchical levels, including specific genes, genes with equivalent functions and even particular amino acid positions. This study improves our knowledge of rapid adaptive radiations and provides new insights into the predictability of evolution.

Vizueta, Joel; Macías-Hernández, Nuria; Arnedo, Miquel A.; Rozas, Julio; Sánchez-Gracia, Alejandro 

Molecular Ecology 28(17): 4028-4045 (2019)
DOIDigital.CSIC

Antimicrobial activity of poly(3,4-ethylenedioxythiophene) n-doped with a pyridinium-containing polyelectrolyte

In spite of p-doped conducting polymers having been widely studied in the last decades and many applications having been developed, studies based on n-doped conducting polymers are extremely scarce. This fact is even more evident when it comes to conducting polymers n-doped with polycations, even though polyanions, such as poly(styrenesulfonate), are often used to obtain p-doped conducting polymers. In this work poly(pyridinium-1,4-diyliminocarbonyl-1,4-phenylene-methylene chloride), abbreviated as P(Py-1,4-P), has been used to prepare n-doped poly(3,4-ethylenedioxythiophene) (PEDOT) electrodes by applying a reduction potential to a de-doped PEDOT film in a P(Py-1,4-P) water solution. The utilization of this cationic polyelectrolyte as an n-dopant agent results in drastic superficial changes, as is observed by comparing the morphology, topography and wettability of p-doped, de-doped and n-doped PEDOT. Cytotoxicity, cell adhesion and cell proliferation assays, which have been conducted using epithelial and fibroblast cell lines, show that the amount of P(Py-1,4-P) in the re-doped PEDOT films is below that required to observe a cytotoxic harmful response and that n-doped PEDOT:P(Py-1,4-P) films are biocompatible. The non-specific bacteriostatic properties of n-doped PEDOT:P(Py-1,4-P) films have been demonstrated against E. coli and S. aureus bacteria (Gram-negative and Gram-positive, respectively) using bacterial growth curves and adhesion assays. Although the bacteriostatic effect is in part due to the conducting polymer, as is proved by results for p-doped and de-doped PEDOT, the incorporation of P(Py-1,4-P) through the re-doping process greatly enhances this antimicrobial behaviour. Thus, only a small concentration of this cationic polyelectrolyte (∼0.1 mM) is needed to inhibit bacterial growth.

Sánchez-Jiménez, Margarita; Estrany, Francesc; Borràs, Nuria; Maiti, Binoy; Díaz Díaz, David ; Del Valle, Luis J.; Alemán, Carlos

Soft Matter 15: 7695-7703 (2019)
DOIDigital.CSIC

5-(1 H-1,2,3-Triazol-5-yl)isophthalic Acid: A Versatile Ligand for the Synthesis of New Supramolecular Metallogels

The gelation ability of 5-(1H-1,2,3-triazol-5-yl)isophthalic acid (click-TIA) in the presence of different metal acetates has been studied in different solvents and ligand/metal ratios. This manuscript is focused on the metallogel obtained from the combination of click-TIA and copper(II) acetate, which has been used as a model system in terms of characterization and gelation studies. Sonication treatment of the initial mixture of compounds and the nature of the counter anion were found to be critical factors for the supramolecular assembly of the metal/click-TIA complexes and, hence, for the formation of stable and homogeneous metallogels. The gel materials have been characterized with a variety of techniques including infrared, rheology, UV-vis spectroscopy, powder X-ray diffraction, and scanning electron microscopy.

Häring, Marleen; Nandi, Sujay Kumar; Rodríguez-López, Julio; Haldar, Debasish; Martín, Victor S.; Lozano-Gorrín, Antonio Diego D.; Saldías, César; Díaz Díaz, David

ACS Omega 4(1): 2111-2117 (2019)
DOIDigital.CSIC

To what extent are bryophytes efficient dispersers?

Bryophytes are typically seen as extremely efficient dispersers. Experimental evidence suggests that efficient short-distance dispersal coupled with random long-distance dispersal (LDD) leads to an inverse isolation effect. Under the latter, a higher genetic diversity of colonizing propagules is expected with increasing isolation, counteracting differentiation beyond the range of short-distance dispersal. This expectation is tested from a review of evidence on spatial genetic structure and analyses of isolation-by-distance (IBD) at different scales. A decay of the IBD signal, characterized by non-significant slopes between kinship coefficients and geographic distance was observed beyond 100 m. A second slope shift was observed at distances larger than 1 km, with a proportion of significant slopes in more than one third of the datasets. The decay of the IBD signal beyond 100 m, which reflects efficient LDD, is consistent with the inverse isolation hypothesis. Persistence of a significant IBD signal at medium ranges in one third of the analysed cases suggests, however, that the inverse isolation effect is not a rule in bryophyte spore dispersal. Furthermore, the higher proportion of significant IBD patterns observed at scales over 100 km likely marks the limits of regional dispersal, beyond which an increasingly smaller proportion of spores travel. Synthesis. We discuss the differences between experimental and genetic estimates of spore dispersal and conclude that geographic distance remains a significant proxy of spore colonization rates, with major consequences for our understanding of actual migration capacities in bryophytes, and hence, our capacity to model range shifts in a changing world.

Vanderpoorten, Alain; Patiño, Jairo; Désamoré, Aurélie; Laenen, Benjamin; Górski, Piotr; Papp, Beata; Holá, Eva; Korpelainen, Helena; Hardy, Olivier

Journal of Ecology 107(5): 2149-2154 (2019)
DOIDigital.CSIC

The discovery of barretonus (Curculionidae: Cossoninae) in the canary islands: Barcoding, morphology and description of new species

The genus Barretonus Roudier, 1958 is a genus endemic to Macaronesia, described from the archipelago of Madeira where four species are known to date. In this study, two new species of Barretonus, B. auarita García & Oromí sp. nov. (from La Palma, Canary Islands) and B. daute García & Andújar sp. nov. (from Tenerife, Canary Islands), are described based on morphological and molecular evidence (mtCOI), and additional notes on their biology and ecology are provided. Morphology of the new species is compared with the other representatives of the genus, and their phylogenetic relationships with a Barretonus representative from Madeira and species from additional genera within the Cossoninae are shown. This work increases the number of species of the genus Barretonus from four to six anophthalmous or microphthalmous species with an endogean lifestyle, and incorporates the Canary Islands into its Macaronesian range of distribution.

García, Rafael; Andújar, Carmelo; Oromí, Pedro; Emerson, Brent C.; López, Heriberto

Acta Entomologica Musei Nationalis Pragae 59(2): 443-452 (2019
DOIDigital.CSIC

Use of a bis-1,2,3-triazole gelator for the preparation of supramolecular metallogels and stabilization of gold nanoparticles

In this work we have applied a double isosteric substitution of the amide groups presented in the gelator N,N′-((1S,2S)-cyclohexane-1,2-diyl)didodecanamide (C-Cyc) by 1,2,3-triazole rings affording the corresponding isosteric gelator (click-C-Cyc). This approach enabled the preparation of different metallogels and fine-tuning their properties. In particular, C-Cyc was found to form stable and reversible metallogels with Pd and Au in DMSO and DMF, whereas click-C-Cyc formed metallogels in these solvents only in the presence of Au. Comparing the gels made of C-Cycvs.click-C-Cyc in the presence of HAuCl·3HO, the former showed higher T values and 5-8 times slower gelation kinetics. Furthermore, the incorporation of EtN as reducing agent in the formulations facilitated the in situ formation of non-aggregated gold nanoparticles embedded in the viscoelastic networks made of either pure isosteres or with an equimolar mixture of click-C-Cyc and C-Cyc. So-formed NPs showed similar size distribution regardless the gold concentration and the nature of the gelator system.

Tautz, Markus; Saldías, César; Lozano-Gorrín, Antonio Diego; Díaz Díaz, David

New Journal of Chemistry 43: 13850-13856 (2019)
DOIDigital.CSIC