Development of more efficient chemical processes with less environmental impact
Sequential processes are developed that link various ionic and radical reactions. Intermediates do not need to be isolated and materials, energy and time are saved, and the waste to be treated is reduced. These processes have been used to manufacture a wide variety of bioactive compounds, such as carbohydrate and nucleotide analogues, unnatural amino acids, peptides and peptidomimetics, or medical probes.
An example of these methodologies would be the modification of carbohydrates, to obtain compounds of pharmacological interest. Thus, using carbohydrate-addition cleavage chain methodologies, cytotoxic/antimicrobial sugars, nucleosides and nucleotides (dioxanes, C-nucleosides) analogues have been prepared. Amino sugars and some hydroxyamino acids have also been modified to obtain sugars. In addition, some of these results have led to licensed patents.