Site-selective peptide modification to develop drugs and peptide catalysts

Selective peptide modification allows easy generation of varied peptide libraries from a few starting substrates, and saves time and resources in the process of drug and peptide catalyst discovery. Our group has introduced "modifiable units" that, once introduced in peptides, can be easily modified without affecting the rest of the residues. Thus, a great variety of amino acids with non-proteinogenic chains, valuable N-alkyl amino acids, β- and γ-amino acids, amino phosphonates, hybrid peptides, etc. have been obtained. These methods are versatile and allow to obtain "peptides on demand" in a very efficient way. Several of the results have been patented and have led to international communications.

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