Molecular Sciences

Functional Molecular Systems

Our main aim is to design and construct functional molecular or supramolecular systems. We are particularly interested in those systems or materials which are able to respond to a stimulus, which triggers a cascade of events, ending up with the desired task. However our lab philosophy is to be always open to new ideas and projects.

The Functional Molecular Systems group profile page on Digital.CSIC.

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FMS
Presentation

Our research group is interested in supramolecular chemistry and stimuli induced processes. We are always trying to make new receptors, molecular capsules or macrocycles, in order to catch interesting compounds. At the same time, we search to modify molecular systems with a specific stimulus (light, chemicals, enzymes…) with the aim of changing their properties, or to release molecular fragments in a controlled manner. Our goal is to apply all that knowledge to real problems, regardless if they are biological, pharmacological or environmental problems. Even preservation of heritage is also tackled. We strongly believe that multidisciplinary research is the only way to approach real-world problems.

Pro-drugs for cancer and neurodegenerative diseases

Traditional cancer chemotherapy lacks any intrinsic selectivity and it is very often accompanied by systemic toxicity to the patient. To circumvent such an inconvenience, we have made novel pro-drugs which are activated under specific conditions on the tumoral micro-environment.

Smart drug carriers

Targeted delivery approach is the long sought aim of drug delivery. In this regard, we have designed and built several nano-carriers in order to transport and release compounds specifically under a biologically relevant stimulus.

Molecular sensors and Theranostics

Detecting a specific compounds among a plethora of other molecules is highly relevant in biomedical research and in several other fields. Additionally it is a truly scientific challenge.

Materials for analytical and environmental applications

We have designed polymers which are able to trap pollutants from water, and additionally those polymers themselves can be decomposed by the right stimulus.

Novel methods of preservation of paper

We have approached paper degradation as if it was a disease, and we have made several pro-drug-like preservants for historical paper documents.

TFM: Pro-fármacos antitumorales inspirados en el ciclo redox de la menadiona promovida por el ascorbato

Sobresaliente

Año:2020
Estudiante:

María Belén González Marrero

Tipo:Máster y TFG

TFG: Síntesis de derivados de ascorbato y menadiona como potenciales antitumorales

Año:2020
Director del trabajo:

Romen Carrillo Fumero y Víctor Martín García

Estudiante:

Elena Henríquez Remón

Tipo:Máster y TFG

Síntesis de Productos de Alto Valor Añadido a Través de Metodologías Sintéticas de Baja Toxicidad

Sobresaliente cum Laude.

Año:2020
Director del trabajo:

Romen Carrillo Fumero y Víctor Martín García

Estudiante:

Diego Manuel Monzón Rodríguez

Tipo:Tesis doctoral

TFM: Self-Immolative Molecular Capsules

Sobresaliente

Año:2020
Estudiante:

David Santana Rivero

Tipo:Máster y TFG

TFM: Sensores moleculares fluorescentes auto-inmolativos

Sobresaliente

Año:2020
Estudiante:

Ana de la Iglesia Pazó

Tipo:Máster y TFG
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Ministerio de Ciencia e Innovación

Química Sostenible: de Moléculas Pequeñas a Sistemas Funcionales Complejos

Estado:

En Ejecución

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TNF

Smart Multi-target Pro-drugs for Huntington (and other Neurodegenerative Diseases)

Investigador principal:

Romen Carrillo Fumero

Estado:

En Ejecución

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MINECO

Cápsulas Moleculares Ensambladas por Enlaces Mecánicos: Una Nueva Aproximación a la Entrega Selectiva de Fármacos

Investigador principal:

Romen Carrillo Fumero

Estado:

Finalizado

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AECC

Pro-fármacos Inteligentes Auto-inmolativos como Nuevos Agentes Antitumorales

Investigador principal:

Romen Carrillo Fumero

Estado:

Finalizado

News/Blog

Selected Publications

Icono de IPNA

Mild-Base-Promoted Arylation of (Hetero)Arenes with Anilines

Transition metal-free radical arylation of heteroarenes is achieved at room temperature by simply adding aqueous sodium carbonate to a solution of the corresponding heteroarene and arenediazonium salt, which can even be formed in situ. Such an easy, inexpensive and mild methodology has been optimized and applied to the expeditious modification of interesting molecular cores like naphthylimide or bisthienylcyclopentenes.

Monzón, Diego M.; Santos, Tanausú; Pinacho Crisóstomo, Fernando R.; Martín, Víctor S.; Carrillo Fumero, Romen 

Chemistry - An Asian Journal 13(3): 325-333 (2018)
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Synthesis of New Benzocyclotrimer

Synthesis of New Benzocyclotrimer Analogues: New Receptors for Tetramethylammonium Ion Recognition

Using a [2 + 2 + 2] cycloaddition/Mitsunobu reaction sequence, a convenient synthesis to access new benzocyclotrimer analogues has been developed. The new receptors have the geometry and functionality capable of recognizing the tetramethylammonium ion in the gas phase and in solution.

Carrillo Fumero, Romen; Hynes, Michael J.; Martín, Víctor S.; Martín, Tomás; Pinacho Crisóstomo, Fernando R.

Organic Letters 17(12): 2912-2915 (2015)
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Ascorbic Acid as an Initiator for the Direct C-H Arylation of (Hetero)arenes with Anilines Nitrosated In Situ

Ascorbic Acid as an Initiator for the Direct C-H Arylation of (Hetero)arenes with Anilines Nitrosated In Situ

Ascorbic acid (vitamin C) has been used as a radical initiator in a metal-free direct CH arylation of (hetero)arenes. Starting from an aniline, the corresponding arenediazonium ion is generated in situ and immediately reduced by vitamin C to an aryl radical that undergoes a homolytic aromatic substitution with a (hetero)arene. Notably, neither heating nor irradiation is required. This procedure is mild, operationally simple, and constitutes a greener approach to arylation.

F. Pinacho Crisóstomo, T Martín, R. Carrillo

Angewandte Chemie - International Edition 53(8): 2181-2185 (2014)
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Radical C-H arylations of (hetero)arenes catalysed by gallic acid

Radical C-H arylations of (hetero)arenes catalysed by gallic acid

Gallic acid efficiently catalyses radical arylations in water–acetone at room temperature. This methodology proved to be versatile and scalable. Therefore, it constitutes a greener alternative to arylation. Moreover, considering that gallic acid is an abundant vegetable tannin, this work also unleashes an alternative method for the reutilisation of bio-wastes.

M. D. Perretti, D. M. Monzón, F. P. Crisóstomo, V. S. Martín, R. Carrillo

Chemical Communications, 2016,52, 9036-9039
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Sustainable oxidations with air mediated by gallic acid

Sustainable oxidations with air mediated by gallic acid: potential applicability in the reutilization of grape pomace

Gallic acid converts atmospheric oxygen into hydrogen peroxide, which is able to oxidize arylboronic acids as a proof of concept of sustainable oxidations. Moreover, tannic acid and grape pomace extract are also able to perform oxidations with air. Therefore this work unleashes an alternative method for reutilization and valorization of bio-wastes rich in tannins.

J. Scoccia, M. D. Perretti, D. M. Monzón, F. P. Crisóstomo, V. S. Martín, R. Carrillo

Green Chemistry, 2016,18, 2647-2650
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Oxidation

Oxidation with air by ascorbate-driven quinone redox cycling

Transition metal-free oxidation with air at room temperature has been achieved by simply using ascorbate (vitamin C) and catalytic amounts of menadione (vitamin K3). A combination of the mentioned vitamins transforms atmospheric oxygen into hydrogen peroxide, which is able to oxidize arylboronic acids and other chemical moieties.

G. Silveira-Dorta, D. M. Monzón, F. P. Crisóstomo, T. Martín, V. S. Martín, R. Carrillo

Chem. Commun, 51(32): 7027-7030 (2015)