Functional Molecular Systems
Our main aim is to design and construct functional molecular or supramolecular systems. We are particularly interested in those systems or materials which are able to respond to a stimulus, which triggers a cascade of events, ending up with the desired task. However our lab philosophy is to be always open to new ideas and projects.
The Functional Molecular Systems group profile page on Digital.CSIC.
Our research group is interested in supramolecular chemistry and stimuli induced processes. We are always trying to make new receptors, molecular capsules or macrocycles, in order to catch interesting compounds. At the same time, we search to modify molecular systems with a specific stimulus (light, chemicals, enzymes…) with the aim of changing their properties, or to release molecular fragments in a controlled manner. Our goal is to apply all that knowledge to real problems, regardless if they are biological, pharmacological or environmental problems. Even preservation of heritage is also tackled. We strongly believe that multidisciplinary research is the only way to approach real-world problems.
Pro-drugs for cancer and neurodegenerative diseases
Traditional cancer chemotherapy lacks any intrinsic selectivity and it is very often accompanied by systemic toxicity to the patient. To circumvent such an inconvenience, we have made novel pro-drugs which are activated under specific conditions on the tumoral micro-environment.
PhD & MSc. Thesis
TFM: Pro-fármacos antitumorales inspirados en el ciclo redox de la menadiona promovida por el ascorbato
TFG: Síntesis de derivados de ascorbato y menadiona como potenciales antitumorales
Síntesis de Productos de Alto Valor Añadido a Través de Metodologías Sintéticas de Baja Toxicidad
TFM: Self-Immolative Molecular Capsules
Mild-Base-Promoted Arylation of (Hetero)Arenes with Anilines
Transition metal-free radical arylation of heteroarenes is achieved at room temperature by simply adding aqueous sodium carbonate to a solution of the corresponding heteroarene and arenediazonium salt, which can even be formed in situ. Such an easy, inexpensive and mild methodology has been optimized and applied to the expeditious modification of interesting molecular cores like naphthylimide or bisthienylcyclopentenes.
Monzón, Diego M.; Santos, Tanausú; Pinacho Crisóstomo, Fernando R.; Martín, Víctor S.; Carrillo Fumero, Romen
Synthesis of New Benzocyclotrimer Analogues: New Receptors for Tetramethylammonium Ion Recognition
Using a [2 + 2 + 2] cycloaddition/Mitsunobu reaction sequence, a convenient synthesis to access new benzocyclotrimer analogues has been developed. The new receptors have the geometry and functionality capable of recognizing the tetramethylammonium ion in the gas phase and in solution.
Carrillo Fumero, Romen; Hynes, Michael J.; Martín, Víctor S.; Martín, Tomás; Pinacho Crisóstomo, Fernando R.
Ascorbic Acid as an Initiator for the Direct C-H Arylation of (Hetero)arenes with Anilines Nitrosated In Situ
Ascorbic acid (vitamin C) has been used as a radical initiator in a metal-free direct CH arylation of (hetero)arenes. Starting from an aniline, the corresponding arenediazonium ion is generated in situ and immediately reduced by vitamin C to an aryl radical that undergoes a homolytic aromatic substitution with a (hetero)arene. Notably, neither heating nor irradiation is required. This procedure is mild, operationally simple, and constitutes a greener approach to arylation.
F. Pinacho Crisóstomo, T Martín, R. Carrillo
Radical C-H arylations of (hetero)arenes catalysed by gallic acid
Gallic acid efficiently catalyses radical arylations in water–acetone at room temperature. This methodology proved to be versatile and scalable. Therefore, it constitutes a greener alternative to arylation. Moreover, considering that gallic acid is an abundant vegetable tannin, this work also unleashes an alternative method for the reutilisation of bio-wastes.
M. D. Perretti, D. M. Monzón, F. P. Crisóstomo, V. S. Martín, R. Carrillo
Sustainable oxidations with air mediated by gallic acid: potential applicability in the reutilization of grape pomace
Gallic acid converts atmospheric oxygen into hydrogen peroxide, which is able to oxidize arylboronic acids as a proof of concept of sustainable oxidations. Moreover, tannic acid and grape pomace extract are also able to perform oxidations with air. Therefore this work unleashes an alternative method for reutilization and valorization of bio-wastes rich in tannins.
J. Scoccia, M. D. Perretti, D. M. Monzón, F. P. Crisóstomo, V. S. Martín, R. Carrillo
Oxidation with air by ascorbate-driven quinone redox cycling
Transition metal-free oxidation with air at room temperature has been achieved by simply using ascorbate (vitamin C) and catalytic amounts of menadione (vitamin K3). A combination of the mentioned vitamins transforms atmospheric oxygen into hydrogen peroxide, which is able to oxidize arylboronic acids and other chemical moieties.
G. Silveira-Dorta, D. M. Monzón, F. P. Crisóstomo, T. Martín, V. S. Martín, R. Carrillo